Inhibitory effect of Murraya koenigii against Candida albicans virulence and biofilm development

被引：0
作者：
Subramanian Muthamil
Shunmugiah Karutha Pandian
机构：
[1] Alagappa University,Department of Biotechnology, Science Campus
来源：
Biologia | 2016年 / 71卷
关键词：
;; biofilm; yeast-to-hyphal transition; drug resistance;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, anti-infective potential of the medicinal plant Murraya koenigii was assessed through in vitro assays and microscopic analysis. The methanolic leaf extract of M. koenigii significantly inhibited the major virulence factors of Candida albicans, such as biofilm formation, yeast-to-hyphal transition, cell surface hydrophobicity, hemolysin production and filamentation. Further purification and molecular characterization of the active lead is expected to give a novel anticandidal agent for the treatment of Candida infection.
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页码：256 / 264
页数：8
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