Intestinal 5-Hydroxytryptamine and Mast Cell Infiltration in Rat Experimental Colitis

被引：0
作者：
F. Magro
S. Fraga
I. Azevedo
P. Soares-Da-Silva
机构：
[1] University of Porto,Institute of Pharmacology and Therapeutics, Faculty of Medicine
[2] University of Porto,Department of Biochemistry (U38/FCT), Faculty of Medicine
[3] Institute of Pharmacology and Therapeutics,Faculty of Medicine
来源：
Digestive Diseases and Sciences | 2006年 / 51卷
关键词：
colitis; 5-hydroxytryptamine; mast cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present study evaluated the extent of dysfunction of the 5-hydroxytryptaminergic system in inflamed (distal colon) and noninflamed segments (jejunum and ileum) after intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in the rat. Dexamethasone was administered to control rats and TNBS-treated animals before and for 7 days after TNBS treatment. Tissue levels of 5-hydroxytryptamine (5-HT) in the inflamed colon were higher than in controls. The densitmast cells was also markedly increased. Treatment with dexamethasone attenuated the inflammatory response but did not prevent the increase in colonic 5-HT. In the noninflamed jejunum and terminal ileum, 5-HT tissue levels were markedly increased, but treatment with dexamethasone prevented this increase. It is concluded that the increase in 5-HT levels in the inflamed colon in TNBS-induced colitis may result fmast cell infiltration. In the noninflamed intestine, 5-HT tissue levels were also increased, favoring the view of a generalized mast cell infiltration.
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页码：495 / 501
页数：6
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