Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo

被引：0

作者：

N. A. Popova

G. M. Sysoeva

V. P. Nikolin

V. I. Kaledin

E. V. Tretyakov

M. V. Edeeva

S. M. Balakhnin

E. L. Lushnikova

G. Audran

S. Mark

机构：

[1] Siberian Division of the Russian Academy of Sciences,Federal Research Institute of Cytology and Genetics

[2] Vektor State Research Center of Virology and Biotechnology,Institute of Medical Biotechnology

[3] Siberian Division of the Russian Academy of Sciences,N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry

[4] Institute of Molecular Pathology and Pathomorphology,undefined

[5] Aix Marseille University,undefined

来源：

Bulletin of Experimental Biology and Medicine | 2017年 / 164卷

关键词：

alkoxyamines; toxicity; tumor cell lines; transplanted tumor strains; phagocytic activity of peritoneal macrophages;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed.

引用

页码：49 / 53

页数：4

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