Comparative Study of Toxicity of Alkoxyamines In Vitro and In Vivo

被引：0
|
作者：
N. A. Popova
G. M. Sysoeva
V. P. Nikolin
V. I. Kaledin
E. V. Tretyakov
M. V. Edeeva
S. M. Balakhnin
E. L. Lushnikova
G. Audran
S. Mark
机构：
[1] Siberian Division of the Russian Academy of Sciences,Federal Research Institute of Cytology and Genetics
[2] Vektor State Research Center of Virology and Biotechnology,Institute of Medical Biotechnology
[3] Siberian Division of the Russian Academy of Sciences,N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry
[4] Institute of Molecular Pathology and Pathomorphology,undefined
[5] Aix Marseille University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2017年 / 164卷
关键词：
alkoxyamines; toxicity; tumor cell lines; transplanted tumor strains; phagocytic activity of peritoneal macrophages;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Effect of alkoxyamines on normal and tumor cells was studied in vitro and in vivo. In vitro experiments showed that alkoxyamines produce a dose-dependent toxic effect on cells of human breast tumor MCF7 line. Transplantation of Krebs-2 ascites carcinoma cells preincubated with alkoxyamines to mice did not induce tumor growth. An opposite effect was observed in normal mouse cells: functional activity of peritoneal macrophages increased. The possibility of using alkoxyamines as theranostic agents is discussed.
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页码：49 / 53
页数：4
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