Role of vascular endothelial growth factor in radiotherapy resistance to esophageal squamous cell carcinoma

被引：0
作者：
Xin Li
Xinyu Su
Chen Yan
Yuanyuan Ma
Heng Li
Jianhong Xia
Hongliang Li
Qian Jiang
Liqing Zhou
Zhengyun Zou
机构：
[1] Huai’an Hospital Affiliated to Xuzhou Medical University,Department of Radiation Oncology
[2] Medical School of Nanjing University,Department of Radiation Oncology, The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Affiliated Drum Tower Hospital
[3] Clinical College of Nanjing Medical University,Department of Radiation Oncology, The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital
[4] Clinical College of Nanjing University of Chinese Medicine,Department of Radiation Oncology, The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital
来源：
Journal of Cancer Research and Clinical Oncology | 2023年 / 149卷
关键词：
Esophageal carcinoma; Vascular endothelial growth factor; Radiotherapy; Curative effect; Anti-angiogenesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Vascular endothelial growth factor (VEGF) is related to the radiation resistance of tumors, resulting in the failure of tumor radiotherapy. The purpose of this study was to discuss the role of VEGF in radiotherapy resistance of esophageal squamous cell carcinoma (ESCC). We used the VEGF kit by ELISA to detect the serum VEGF level of ESCC patients who only received radiotherapy. The expression of VEGF in ESCC cells after siRNA treatment was verified by Western blot. The sensitivity of ESCC cells to radiation after knocking down VEGF was analyzed by Clonogenic assay and Cell counting kit (CCK-8). The results showed that the level of serum VEGF in patients with ESCC before and after radiotherapy was related to the clinical response, and it was confirmed that knocking down the expression of VEGF in ESCC cells improved the sensitivity to radiation.
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页码：2543 / 2550
页数：7
相关论文
共 228 条
[1]  
Buckley AM(2020)Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers Nat Rev Gastroenterol Hepatol 17 298-313
[2]  
Lynam-Lennon N(2015)Combining radiation with autophagy inhibition enhances suppression of tumor growth and angiogenesis in esophageal cancer Mol Med Rep 12 1645-1652
[3]  
O’Neill H(2020)VEGF knockdown enhances radiosensitivity of nasopharyngeal carcinoma by inhibiting autophagy through the activation of mTOR pathway Sci Rep 10 16328-9
[4]  
O’Sullivan J(2021)Epidemiology, diagnosis, staging and multimodal therapy of esophageal and gastric tumors Cancers 13 582-247
[5]  
Chen Y(2021)Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF1α and VEGF expression Mol Med Rep 23 1-129
[6]  
Li X(2009)New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) Eur J Cancer 45 228-88
[7]  
Guo L(2018)Antiangiogenic therapy: markers of response, “normalization” and resistance Crit Rev Oncol Hematol 128 118-137
[8]  
Xiaoyuan Wu(2015)Bevacizumab radiosensitizes non-small cell lung cancer xenografts by inhibiting DNA double-strand break repair in endothelial cells Cancer Lett 365 79-101
[9]  
He C(2017)The effect of anti-angiogenic drugs on regulatory T cells in the tumor microenvironment Biomed Pharmacother 88 134-630
[10]  
Zhang S(2012)Nonangiogenic function of VEGF and enhanced radiosensitivity of HeLa cells by inhibition of VEGF expression Oncol Res Featur Preclin Clin Cancer Ther 20 93-1899
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