Citric acid, a green catalyst for the one-pot, multi-component synthesis of highly substituted piperidines

被引:0
作者
Zahra Madanifar
Malek-Taher Maghsoodlou
Mehrnoosh Kangani
Nourallah Hazeri
机构
[1] University of Sistan and Baluchestan,Department of Chemistry
来源
Research on Chemical Intermediates | 2015年 / 41卷
关键词
Citric acid; Green catalyst; Highly substituted piperidines; β-Ketoesters;
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学科分类号
摘要
Citric acid has been used as a green and efficient catalyst for one-pot, multi-component synthesis of highly substituted piperidines by condensation of aromatic aldehydes, aromatic amines, and β-ketoesters in MeOH at ambient temperature. This method has several advantages including use of a nonhazardous and inexpensive catalyst, easy work-up, clean reaction conditions, and high yields.
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页码:9863 / 9869
页数:6
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  • [1] Tanaka H(1987)undefined J. Am. Chem. Soc. 109 5031-undefined
  • [2] Kuroda A(1996)undefined J. Am. Chem. Soc. 118 1629-undefined
  • [3] Marusawa H(2004)undefined Acc. Chem. Res. 37 365-undefined
  • [4] Hatanaka H(2008)undefined J. Org. Chem. 73 5319-undefined
  • [5] Kino T(2006)undefined J. Am. Chem. Soc. 128 9066-undefined
  • [6] Goto T(2007)undefined Tetrahedron Lett. 48 6258-undefined
  • [7] Hashimoto M(1983)undefined Phytochemistry 22 1615-undefined
  • [8] Taga T(1986)undefined J. Neural Transm. 67 175-undefined
  • [9] Boger DL(1952)undefined J. Am. Chem. Soc. 74 2949-undefined
  • [10] Chen JH(1998)undefined Tetrahedron Asymmetry 9 4361-undefined