The involvement of actin cytoskeleton in glutoxim and molixan effect on intracellular Ca2+-concentration in macrophages

被引：0
|
作者：
L. S. Kurilova
Z. I. Krutetskaya
O. E. Lebedev
N. I. Krutetskaya
V. G. Antonov
机构：
[1] Chair of Biophysics of St. Petersburg State University,
来源：
Cell and Tissue Biology | 2012年 / 6卷 / 3期
关键词：
peritoneal macrophages; glutoxim; molixan; intracellular Ca; -concentration; actin filaments;
D O I：
10.1134/S1990519X12030066
中图分类号：
学科分类号：
摘要：
Glutoxim and molixan belong to new generation of disulfide-containing drugs with immunomodulatory, hepatoprotective and hemopoetic effect on cells. Using Fura-2AM microfluorimetry, two structurally distinct actin filament disrupters latrunculin B and cytochalasin D, and calyculin A, which causes actin filaments condensation under plasmalemma, we have shown the involvement of actin cytoskeleton in the intracellular Ca2+-concentration increase induced by glutoxim or molixan in rat peritoneal macrophages. Morphological data obtained with the use of rhodamine-phalloidine demonstrated that glutoxim and molixan cause the actin filaments reorganization in rat peritoneal macrophages.
引用
收藏
页码：240 / 247
页数：7
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