Novel catalysts for the enantioselective Henry reaction

被引：0
作者：
V. V. Veselovsky
A. V. Stepanov
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
来源：
Russian Chemical Bulletin | 2014年 / 63卷
关键词：
enantioselective synthesis; nitroaldol condensation; Henry reaction; copper(; ) complexes; (; )-diphenylprolinol;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Two novel catalytic systems based on the CuII complexes with N-(3,5-dibromo-2-hydroxybenzyl)- and N-(2-hydroxy-3-nitrobenzyl)-(S)-α,α-diphenylprolinols were developed. These systems catalyze the condensation of 4-nitrobenzaldehyde with nitromethane to produce S-nitroaldol with maximum enantiomeric excess of >90% (99% yield). The reactions of nitromethane with aliphatic aldehydes give the corresponding products in the yields above 80% and ee > 90%.
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页码：422 / 425
页数：3
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