Long-term c-Kit overexpression in beta cells compromises their function in ageing mice

被引:0
|
作者
Amanda Oakie
Zhi-Chao Feng
Jinming Li
Jenna Silverstein
Siu-Pok Yee
Rennian Wang
机构
[1] University of Western Ontario,Children’s Health Research Institute
[2] Victoria Research Laboratories,Department of Pathology and Laboratory Medicine
[3] University of Western Ontario,Department of Physiology and Pharmacology
[4] University of Western Ontario,Department of Cell Biology
[5] University of Connecticut Health Center,Department of Medicine
[6] Department of Genetics and Genome Sciences,undefined
[7] University of Connecticut Health Center,undefined
[8] University of Western Ontario,undefined
来源
Diabetologia | 2019年 / 62卷
关键词
c-Kit; Insulin receptor; IRS-1 serine phosphorylation; MIP-CreER mouse model; Receptor tyrosine kinase; SNARE; Tamoxifen-induced;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1430 / 1444
页数:14
相关论文
共 50 条
  • [1] Long-term c-Kit overexpression in beta cells compromises their function in ageing mice
    Oakie, Amanda
    Feng, Zhi-Chao
    Li, Jinming
    Silverstein, Jenna
    Yee, Siu-Pok
    Wang, Rennian
    DIABETOLOGIA, 2019, 62 (08) : 1430 - 1444
  • [2] Long-term overexpression of c-Kit negatively impacts beta cell function and survival via capillary and inflammatory recruitment in the islet
    Feng, Z-C
    Li, J.
    Silverstein, J.
    Popell, A.
    Yee, S-P
    Wang, R.
    DIABETOLOGIA, 2013, 56 : S222 - S222
  • [3] Overexpression of c-Kit in agedmice stimulates beta cell proliferation, but leads to impaired beta cell function
    Oakie, A. M.
    Feng, Z. -C.
    Li, J.
    Silverstein, J.
    Wang, R.
    DIABETOLOGIA, 2017, 60 : S102 - S102
  • [4] Transcription factor SCL is required for c-kit expression and c-kit function in hemopoietic cells
    Krosl, G
    He, G
    Lefrancois, M
    Charron, F
    Roméo, PH
    Jolicoeur, P
    Kirsch, IR
    Nemer, M
    Hoang, T
    JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (03): : 439 - 450
  • [5] Transcription factor SCL is required for C-Kit expression and C-Kit function in hemopoietic cells.
    Krosl, G
    He, G
    Lefrancois, M
    Charron, F
    Roméo, PH
    Jolicoeur, P
    Kirsch, IR
    Nemer, M
    Hoang, T
    EXPERIMENTAL HEMATOLOGY, 1998, 26 (08) : 741 - 741
  • [6] EXPRESSION AND FUNCTION OF C-KIT IN HEMATOPOIETIC PROGENITOR CELLS
    OGAWA, M
    MATSUZAKI, Y
    NISHIKAWA, S
    HAYASHI, SI
    KUNISADA, T
    SUDO, T
    KINA, T
    NAKAUCHI, H
    NISHIKAWA, SI
    JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (01): : 63 - 71
  • [7] Expression of c-kit and Cytokeratin 5 in the Submandibular Gland after Release of Long-Term Ligation of the Main Excretory Duct in Mice
    Watanabe, Hiroshi
    Takahashi, Haruka
    Hata-Kawakami, Miyuki
    Tanaka, Akira
    ACTA HISTOCHEMICA ET CYTOCHEMICA, 2017, 50 (03) : 111 - 118
  • [8] c-kit(+) Stem cells and thymocyte precursors in the livers of adult mice
    Watanabe, H
    Miyaji, C
    Seki, S
    Abo, T
    JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02): : 687 - 693
  • [9] Long-term empagliflozin treatment preserves beta cell function in ageing ZDF rats
    Pepin, E.
    Sulpice, T.
    Mark, M.
    Mayoux, E.
    Alquier, T.
    Poitout, V.
    DIABETOLOGIA, 2014, 57 : S324 - S324
  • [10] C-KIT receptor maintains cardiac function in aging mice post MI
    Ayach, Bilal B.
    Maekawa, Yuichiro
    Dawood, Fayez
    Chen, Manyin
    Arab, Sara
    Wadhawan, Sachin
    Liu, Peter P.
    JOURNAL OF CARDIAC FAILURE, 2006, 12 (06) : S41 - S41