Primary mediastinal B-cell lymphoma

被引:0
作者
Alev Brown
Tomoko Tagawa
机构
[1] Harbor-UCLA Medical Center,Division of Hematology and Medical Oncology
来源
Current Respiratory Care Reports | 2014年 / 3卷 / 4期
关键词
Primary mediastinal; B-cell lymphoma; Rituximab; Radiotherapy;
D O I
10.1007/s13665-014-0087-z
中图分类号
学科分类号
摘要
Primary mediastinal B-cell lymphoma is an established subtype of non-Hodgkin Lymphoma with distinguishable histopathological and clinical features. It characteristically presents with a bulky mediastinal mass and in a younger, predominantly female population. Advanced age, high LDH levels, and poor performance status are associated with poorer prognosis. Endobronchial ultrasound-guided transbronchial needle aspiration may be a valuable tool for establishing the diagnosis. At a molecular level, it has overlapping traits with nodular sclerosis classical Hodgkin Lymphoma. There is a variety of treatment options, with no standardized regimen. The use of rituximab combined with chemotherapy has correlated with good outcomes. The use of consolidative radiotherapy is controversial, with questionable benefit and established long-term toxicity, including secondary malignancy and cardiovascular disease. An FDG-PET scan is indicated when monitoring for response, because a residual mediastinal mass is commonly seen upon treatment completion but does not always indicate active disease. Relapse usually occurs within the first year, but overall survival is similar to that for diffuse large B-cell lymphoma.
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页码:187 / 191
页数:4
相关论文
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