Circular RNAs in renal cell carcinoma: from mechanistic to clinical perspective

被引：0

作者：

Chunjie Huang

Pooya Esfani Sarafraz

Parisa Enayati

Elham Mortazavi Mamaghani

Emad Babakhanzadeh

Majid Nazari

机构：

[1] Nantong University,School of Medicine

[2] Guilan University of Medical Sciences,Department of Pharmacy

[3] Northern Illinois University,Biological Sciences Department

[4] Iran University of Medical Sciences,Department of Medicine

[5] Shahid Beheshti University of Medical Sciences,Department of Medical Genetics

[6] Shahid Sadoughi University of Medical Sciences,Department of Medical Genetics

来源：

Cancer Cell International | / 23卷

关键词：

CircRNA; Renal cell carcinoma; Biomarker; Targeted therapy;

D O I：

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摘要：

CircRNAs, a special type of noncoding RNAs characterized by their stable structure and unique abilities to form backsplicing loops, have recently attracted the interest of scientists. These RNAs are abundant throughout the body and play important roles such as microRNA sponges, templates for transcription, and regulation of protein translation and RNA-binding proteins. Renal cancer development is highly correlated with abnormal circRNA expression in vivo. CircRNAs are currently considered promising targets for novel therapeutic approaches as well as possible biomarkers for prognosis and diagnosis of various malignancies. Despite our growing understanding of circRNA, numerous questions remain unanswered. Here, we address the characteristics of circRNAs and their function, focusing in particular on their impact on drug resistance, metabolic processes, metastasis, cell growth, and programmed cell death in renal cancer. In addition, the application of circRNAs as prognostic and diagnostic biomarkers will be discussed.

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