The Role of MicroRNAs and Their Targets in Osteoarthritis

被引：0
作者：
Gregory R. Sondag
Tariq M. Haqqi
机构：
[1] Northeast Ohio Medical University (NEOMED),Department of Anatomy and Neurobiology
来源：
Current Rheumatology Reports | 2016年 / 18卷
关键词：
Osteoarthritis; MicroRNA; Targets; Inflammation; Cartilage;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Micro ribonucleic acid (microRNA) regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Several studies have focused on specific microRNAs that are differentially expressed in cases of osteoarthritis. Furthermore, several targets of these miRNAs important in disease progression have also been identified. In this review, we focus on microRNA biogenesis, regulation, detection, and quantification with an emphasis on cellular localization and how these concepts may be linked to disease processes such as osteoarthritis. Next, we review the relationships of specific microRNAs to certain features and risk factors associated with osteoarthritis such as inflammation, obesity, autophagy, and cartilage homeostasis. We also identify certain microRNAs that are differentially expressed in osteoarthritis but have unidentified targets and functions in the disease state. Lastly, we identify the potential use of microRNAs for therapeutic purposes and also mention certain remedies that regulate microRNA expression.
引用
收藏
相关论文
共 835 条
  • [1] Vennu V(2014)Relationship between falls, knee osteoarthritis, and health-related quality of life: data from the Osteoarthritis Initiative study Clin Interv Aging 9 793-800
  • [2] Bindawas SM(1993)The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 Cell 75 843-54
  • [3] Lee RC(2016)MicroRNAs in obesity-associated disorders Arch Biochem Biophys 589 108-19
  • [4] Feinbaum RL(2011)Pervasive roles of microRNAs in cardiovascular biology Nature 469 336-42
  • [5] Ambros V(2006)A microRNA expression signature of human solid tumors defines cancer gene targets Proc Natl Acad Sci U S A 103 2257-61
  • [6] Abente EJ(2015)MicroRNAs’ involvement in osteoarthritis and the prospects for treatments Evid Based Complement Alternat Med 2015 236179-80
  • [7] Subramanian M(2016)MicroRNAs: exploring new horizons in osteoarthritis Osteoarthr Cartil 24 573-611
  • [8] Ramachandran V(2015)Noncoding RNAs, cytokines, and inflammation-related diseases FASEB J 29 3595-39
  • [9] Najafi-Shoushtari SH(2008)Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology PLoS One 3 e2818-60
  • [10] Small EM(2009)Biogenesis of small RNAs in animals Nat Rev Mol Cell Biol 10 126-66
12345678910