Alendronate associated focal segmental glomerulosclerosis: a case report and review of the literature

被引：0

作者：

Pranav S. Garimella

Helmut G. Rennke

James A. Strom

机构：

[1] Tufts Medical Center,Division of Nephrology

[2] Brigham and Women’s Hospital,Division of Pathology

[3] St. Elizabeth Medical Center,Division of Nephrology

来源：

CEN Case Reports | 2015年 / 4卷 / 1期

关键词：

Alendronate; Bisphosphonate; Collapsing glomerulosclerosis; Dialysis; FSGS; Proteinuria;

D O I：

10.1007/s13730-014-0132-3

中图分类号：

学科分类号：

摘要：

Although kidney injury associated with intravenous bisphosphonate therapy is well documented, there are very few reported instances of oral bisphosphonate therapy leading to focal segmental glomerulosclerosis (FSGS) and kidney failure. We report the case of a 79-year-old woman who developed acute kidney injury due to collapsing FSGS while receiving therapy with weekly oral alendronate therapy for osteoporosis. Withdrawal of alendronate and treatment with corticosteroids resulted in partial recovery of kidney function for a period of 16 months until she developed progressive kidney failure needing long-term dialysis. This case report and the literature review highlight the fact that oral bisphosphonates may be associated with a risk of developing FSGS.

引用

页码：20 / 23

页数：3

共 20 条

[1]

Markowitz GS(2001)Collapsing focal segmental glomerulosclerosis following treatment with high-dose pamidronate J Am Soc Nephrol. 12 1164-1172

[2]

Barri YM(2004)Podocyte injury associated glomerulopathies induced by pamidronate Kidney Int. 65 634-641

[3]

Desikan R(2002)Nephrotic proteinuria associated with high-dose pamidronate in multiple myeloma Br J Haematol. 119 496-499

[4]

Sauter M(2006)Nephrotic-range proteinuria following pamidronate therapy in a patient with metastatic breast cancer: mitochondrial toxicity as a pathogenetic concept? Am J Kidney Dis. 47 1075-1080

[5]

Shreedhara M(2007)Reversibility of pamidronate-associated glomerulosclerosis Proc (Bayl Univ Med Cent). 20 249-253

[6]

Miura N(2009)Massive proteinuria and acute renal failure after oral bisphosphonate (alendronate) administration in a patient with focal segmental glomerulosclerosis Clin Exp Nephrol. 13 85-88

[7]

Pascual J(2007)Collapsing focal segmental glomerulosclerosis in a liver transplant recipient on alendronate Osteoporos Int. 18 1435-1438

[8]

Prikis M(2009)Alendronate-associated focal segmental glomerulosclerosis NDT Plus. 2 91-92

[9]

Gibson PC(2012)Nephrotic syndrome after oral bisphosphonate (alendronate) administration in a patient with osteoporosis Osteoporos Int. 23 2059-2062

[10]

Weise WJ(2002)Relapse of nephrotic syndrome triggered by biphosphonates Nephrol Dial Transplant. 17 1856-1857

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