The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27–CD70 interactions

被引：0
作者：
Sonia Feau
Zacarias Garcia
Ramon Arens
Hideo Yagita
Jannie Borst
Stephen P. Schoenberger
机构：
[1] Laboratory of Cellular Immunology,Department of Immunology
[2] La Jolla Institute for Allergy and Immunology,Division of Immunology
[3] Juntendo University School of Medicine,undefined
[4] 2-1-1 Hongo,undefined
[5] Bunkyo-ku,undefined
[6] Tokyo 113-8421,undefined
[7] Japan.,undefined
[8] The Netherlands Cancer Institute,undefined
[9] Plesmanlaan 121,undefined
[10] 1066 CX Amsterdam,undefined
[11] The Netherlands.,undefined
[12] Present address: Institut Pasteur,undefined
[13] Unité 'Dynamique des Réponses Immunes',undefined
[14] INSERM U668,undefined
[15] 25 rue du Docteur Roux,undefined
[16] 75724 PARIS Cedex 15,undefined
[17] France.,undefined
[18] Present address: Department of Immunohematology and Blood Transfusion,undefined
[19] Leiden University Medical Center,undefined
[20] 2333ZA,undefined
[21] The Netherlands.,undefined
来源：
Nature Communications | / 3卷
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摘要：
CD8+ cytotoxic T lymphocytes are critical components of immunity against infectious pathogens, tumours, and in the case of pathogenic autoimmunity, normal self tissues. CD4+ T (TH) cells provide 'help' to CD8+ cytotoxic T lymphocytes during priming by first activating antigen-presenting cells via CD40–CD40L interactions. Here we show that, after immunization with either a noninflammatory, nonreplicating antigen or an overtly inflammatory replicating antigen, CD8+ cytotoxic T lymphocytes prevented from receiving a signal through CD27 during priming subsequently exhibit a specific defect in their capacity for secondary expansion that can be rescued by the absence of TRAIL. Thus, the 'help message' is transmitted to CD8+ T cells via CD70–CD27 signals, enabling them to undergo secondary expansion and avoid TRAIL-mediated apoptosis on re-stimulation. These findings complete our understanding of the cellular interactions through which TH is provided to CD8+ cytotoxic T lymphocytes during priming.
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