Interactions Between Genotype and Depressive Symptoms on Obesity

被引：0
作者：
Bernard F. Fuemmeler
Tanya Agurs-Collins
F. Joseph McClernon
Scott H. Kollins
Melanie E. Garrett
Allison E. Ashley-Koch
机构：
[1] Duke University Medical Center,
来源：
Behavior Genetics | 2009年 / 39卷
关键词：
Depression; Obesity; SLC6A4; MAOA; Gender;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Depression and Genetic variation in serotonin and monoamine transmission have both been associated with body mass index (BMI), but their interaction effects are not well understood. We examined the interaction between depressive symptoms and functional polymorphisms of serotonin transporter (SLC6A4) and monoamine oxidase A (MAOA) on categories of BMI. Participants were from the National Longitudinal Study of Adolescent Health. Multiple logistic regression was used to investigate interactions between candidate genes and depression on risk of obesity (BMI ≥ 30) or overweight + obese combined (BMI ≥ 25). Males with an MAOA active allele with high depressive symptoms were at decreased risk of obesity (OR 0.22; 95% CI 0.06–0.78) and overweight + obesity (OR 0.48; 95% CI 0.26–0.89). No similar effect was observed among females. These findings highlight that the obesity–depression relationship may vary as a function of gender and genetic polymorphism, and suggest the need for further study.
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页码：296 / 305
页数：9
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