Experience in the Use of Solid-Phase Extraction in the Screening of Pharmaceuticals and Narcotics in the Blood by Gas Chromatography with Mass Spectrometric Detection

被引：0

作者：

O. N. Dvorskaya

I. P. Krokhin

S. S. Kataev

机构：

[1] Perm State Pharmaceutical Academy,

[2] Ministry of Health of the Russian Federation,undefined

[3] Perm Regional Bureau of Forensic Medical Examination,undefined

来源：

Pharmaceutical Chemistry Journal | 2017年 / 51卷

关键词：

methylenedioxypyrovalerone; pyrrolidinovalerophenone; narcotic screening; cannabimimetics; blood; solid-phase extraction;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Studies using 224 blood samples as examples showed that the use of solid-phase extraction and gas chromatography with mass spectrometric detection for screening blood provides reliable identification of a wide range of narcotic and pharmaceutical substances of forensic medical interest, including “designer” synthetic narcotics – methylenedioxypyrovalerone (MDPV), pyrrolidinovalerophenone (PVP), and their metabolites; cannabimimetic metabolites N-(1-carbamoyl-2-methylpropyl)-1-pentyl-1H-indazole-3-carboxamide (ABPINACA) and/or N-[(1-pentyl-1H-indazol-3-yl)carbonyl]valine methyl ester (AMB). The distribution of substances in different elusion fractions is given and dissociation constants (pKa) and coefficients of distribution in an octanol-water system (log P) are calculated.

引用

页码：216 / 221

页数：5