MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers

被引：0
作者：
Hao Jia
Le Kang
Zhen Ma
Shuyang Lu
Ben Huang
Chunsheng Wang
Yunzeng Zou
Yongxin Sun
机构：
[1] Zhongshan Hospital,Department of Cardiac Surgery
[2] Fudan University,Central Laboratory of Cardiovascular Institute
[3] Zhongshan Hospital,undefined
[4] Fudan University,undefined
来源：
Journal of Cardiothoracic Surgery | / 16卷
关键词：
miRNA; Aneurysm; Bicuspid aortic valve; Mechanism; Biomarker;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The incidence of bicuspid aortic valves (BAV) is high in the whole population, BAV-related thoracic aortic aneurysm (TAA) is accompanied by many adverse vascular events. So far, there are two key points in dealing with BAV-related TAA. First is fully understanding on its pathogenesis. Second is optimizing surgical intervention time. This review aims to illustrate the potential role of miRNAs in both aspects, that is, how miRNAs are involved in the occurrence and progression of BAV-related TAA, and the feasibilities of miRNAs as biomarkers.
引用
收藏
相关论文
共 76 条
  • [1] Ward C(2000)Clinical significance of the bicuspid aortic valve Heart 83 81-85
  • [2] Trimarchi S(2005)Contemporary results of surgery in acute type A aortic dissection: the International Registry of Acute Aortic Dissection experience J Thorac Cardiovasc Surg 129 112-122
  • [3] Davies RR(2002)Yearly rupture or dissection rates for thoracic aortic aneurysms: simple prediction based on size Ann Thorac Surg 73 17-27
  • [4] Pape LA(2007)Aortic diameter >or = 5.5 cm is not a good predictor of type A aortic dissection: observations from the International Registry of Acute Aortic Dissection (IRAD) Circulation 116 1120-1127
  • [5] Hiratzka LF(2010)2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the diagnosis and management of patients with thoracic aortic disease: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Soci
  • [6] Andreassi MG(2016)Genetics of bicuspid aortic valve aortopathy Curr Opin Cardiol 31 585-592
  • [7] Della Corte A(2012)The congenital bicuspid aortic valve can experience high-frequency unsteady shear stresses on its leaflet surface Am J Physiol Heart Circ Physiol 303 H721-H731
  • [8] Yap CH(2019)Regulation of microRNA function in animals Nat Rev Mol Cell Biol 20 21-37
  • [9] Gebert LFR(2009)MicroRNAs: target recognition and regulatory functions Cell 136 215-233
  • [10] MacRae IJ(2011)Emerging complexity of microRNA generation cascades J Biochem 149 15-25
12345678