Dopamine D4 Receptor Gene: Novelty or Nonsense?

被引:0
作者
Andrew D Paterson
Glen A Sunohara
James L Kennedy
机构
[1] Neurogenetics Section,Clarke Division, Department of Psychiatry
[2] Center for Addiction and Mental Health,undefined
[3] University of Toronto,undefined
[4] Novartis Pharma Canada Inc.,undefined
来源
Neuropsychopharmacology | 1999年 / 21卷
关键词
Dopamine D4 receptor gene; Association; Novelty seeking; Alcoholism; Drug abuse; ADHD, DRD4; Review;
D O I
暂无
中图分类号
学科分类号
摘要
Although the role of genetics in personality has been studied extensively at a phenomenological level, only lately has the investigation of specific genes been performed. Recent reports suggest that DNA variants of the dopamine D4 receptor gene (DRD4) are associated with the personality trait of novelty seeking; however, others fail to replicate this finding. Such conflicting results suggest either a weak effect, an association only in certain populations, or a false-positive resulting from population stratification. We provide a critical analysis of genetic studies of DRD4 variants with novelty seeking, alcoholism, drug abuse, and attention deficit hyperactivity disorder. Evidence for the role of DRD4 in novelty seeking is inconclusive, with a number of methodological concerns. Use of more conservative statistical criteria for significance, employing gene haplotypes, as well as linkage disequilibrium studies, are recommended. The molecular biology of the D4 gene is also reviewed.
引用
收藏
页码:3 / 16
页数:13
相关论文
共 50 条
  • [31] Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype
    Vaughn, Michael G.
    Beaver, Kevin M.
    DeLisi, Matt
    Howard, Matthew O.
    Perron, Brian E.
    [J]. ALCOHOL, 2009, 43 (03) : 179 - 184
  • [32] Molecular and behavioral analysis of the intron 2 repeat polymorphism in the canine dopamine D4 receptor gene
    Hejjas, K.
    Kubinyi, E.
    Ronai, Z.
    Szekely, A.
    Vas, J.
    Miklosi, A.
    Sasvari-Szekely, M.
    Kereszturi, E.
    [J]. GENES BRAIN AND BEHAVIOR, 2009, 8 (03) : 330 - 336
  • [33] Dopamine D4 receptor polymorphism and idiopathic Parkinson's disease
    Kronenberg, MF
    Menzel, HJ
    Ebersbach, G
    Wenning, GK
    Luginger, E
    Gollner, M
    Ransmayr, G
    Utermann, G
    Poewe, W
    Kronenberg, F
    [J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 1999, 7 (03) : 397 - 400
  • [34] Dopamine D4 receptor polymorphism and idiopathic Parkinson's disease
    Martina F Kronenberg
    Hans-Jürgen Menzel
    Georg Ebersbach
    Gregor K Wenning
    Elisabeth Luginger
    Martin Gollner
    Gerhard Ransmayr
    Gerd Utermann
    Werner Poewe
    Florian Kronenberg
    [J]. European Journal of Human Genetics, 1999, 7 : 397 - 400
  • [35] Dopamine D4 receptor gene expression plays important role in extinction and reinstatement of cocaine-seeking behavior in mice
    Ananth, Mala
    Hetelekides, Eleftherios M.
    Hamilton, John
    Thanos, Panayotis K.
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2019, 365 : 1 - 6
  • [36] D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking
    Helms, C. M.
    Gubner, N. R.
    Wilhelm, C. J.
    Mitchell, S. H.
    Grandy, D. K.
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2008, 90 (03) : 387 - 393
  • [37] The dopamine D4 receptor gene (DRD4) is not associated with alcoholism in three Taiwanese populations: Six polymorphisms tested separately and as haplotypes
    Chang, FM
    Ko, HC
    Lu, RB
    Pakstis, AJ
    Kidd, KK
    [J]. BIOLOGICAL PSYCHIATRY, 1997, 41 (04) : 394 - 405
  • [38] Association between the type 4 dopamine receptor gene polymorphism and novelty seeking
    Keltikangas-Järvinen, L
    Elovainio, M
    Kivimäki, M
    Lichtermann, D
    Ekelund, J
    Peltonen, L
    [J]. PSYCHOSOMATIC MEDICINE, 2003, 65 (03): : 471 - 476
  • [39] The association between creativity and 7R polymorphism in the dopamine receptor D4 gene (DRD4)
    Mayseless, Naama
    Uzefovsky, Florina
    Shalev, Idan
    Ebstein, Richard P.
    Shamay-Tsoory, Simone G.
    [J]. FRONTIERS IN HUMAN NEUROSCIENCE, 2013, 7
  • [40] Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking
    Ebstein, RP
    Nemanov, L
    Klotz, I
    Gritsenko, I
    Belmaker, RH
    [J]. MOLECULAR PSYCHIATRY, 1997, 2 (06) : 472 - 477