Zinc toxicity in various lung cell lines is mediated by glutathione and GSSG reductase activity

被引：0
|
作者：
U. I. Walther
B. Wilhelm
S. Walther
H. Mückter
B. Fichtl
机构：
[1] Walther Straub-Institut für Pharmakologie und Toxikologie der Ludwig-Maximilians Universität München,
来源：
Biological Trace Element Research | 2000年 / 78卷
关键词：
GSH; glutathione; zinc toxicity; lung cell lines; GSSG reductase;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In a previous work, it was shown that in cells after a decrease of cellular glutathione content, toxic zinc effects, such as protein synthesis inhibition or GSSG (glutathione, oxidized form) increases, were enhanced. In this study, zinc toxicity was determined by detection of methionine incorporation as a parameter of protein synthesis and GSSG increase in various lung cell lines (A549, L2, 11Lu, 16Lu), dependent on enhanced GSSG reductase activities and changed glutathione contents.
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页码：163 / 177
页数：14
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