Inhibition of XPO1 with KPT-330 induces autophagy-dependent apoptosis in gallbladder cancer by activating the p53/mTOR pathway

被引：0
|
作者：
Cheng Zhao
Zi-yi Yang
Jian Zhang
Ou Li
Shi-lei Liu
Chen Cai
Yi-jun Shu
Li-jia Pan
Wei Gong
Ping Dong
机构：
[1] Xinhua Hospital Affiliated With Shanghai Jiao Tong University School of Medicine,Laboratory of General Surgery and Department of General Surgery
[2] Shanghai Key Laboratory of Biliary Tract Disease Research,undefined
来源：
Journal of Translational Medicine | / 20卷
关键词：
Chromosome region maintenance 1; Gallbladder cancer; KPT-330; Apoptosis; Autophagy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 44 条
  • [21] Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway
    Heng Zhang
    Yunping Jiao
    Chunyang Shi
    Xiao Song
    Ying Chang
    Yong Ren
    Xiaolin Shi
    Cytotechnology, 2018, 70 : 321 - 329
  • [22] Ginsenoside Rg1 Induces Autophagy in Colorectal Cancer through Inhibition of the Akt/mTOR/p70S6K Pathway
    Liu, Ruiqi
    Zhang, Bin
    Zou, Shuting
    Cui, Li
    Lin, Lin
    Li, Lingchang
    JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2024, 34 (04) : 774 - 782
  • [23] Transforming growth factor-beta 1 induces apoptosis in gastric cancer cells through a p53 independent pathway
    Yamamoto, M
    Maehara, Y
    Sakaguchi, Y
    Kusumoto, T
    Ichiyoshi, Y
    Sugimachi, K
    CANCER, 1996, 77 (08) : 1628 - 1633
  • [24] LncRNA RHPN1-AS1 inhibition induces autophagy and apoptosis in prostate cancer cells via the miR-7-5p/EGFR/PI3K/AKT/mTOR signaling pathway
    Ma, Xiulong
    Ren, Hongtao
    Zhang, Yang
    Wang, Baofeng
    Ma, Hongbing
    ENVIRONMENTAL TOXICOLOGY, 2022, 37 (12) : 3013 - 3027
  • [25] Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway
    Lin, JG
    Chen, GW
    Li, TM
    Chouh, ST
    Tan, TW
    Chung, JG
    JOURNAL OF UROLOGY, 2006, 175 (01) : 343 - 347
  • [26] RASSF10 is Epigenetically Inactivated and Suppresses Cell Proliferation and Induces Cell Apoptosis by Activating the p53 Signalling Pathway in Papillary Thyroid Carcinoma Cancer
    Fan, Cheng
    Wang, Wendy
    Jin, Ji
    Yu, Zhuo
    Xin, Xiping
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 41 (03) : 1229 - 1239
  • [27] Atractylodin induces oxidative stress-mediated apoptosis and autophagy in human breast cancer MCF-7 cells through inhibition of the P13K/Akt/mTOR pathway
    Li, Zuowei
    Song, YeLin
    Hou, Wangjun
    Qi, Yingzi
    Lu, Xuxiang
    Xue, Ye
    Huang, Jie
    Fang, Qiong
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2022, 36 (08)
  • [28] FLLL12 induces apoptosis in lung cancer cells through a p53/p73-independent but death receptor 5-dependent pathway
    Haque, Abedul
    Rahman, Mohammad A.
    Fuchs, James R.
    Chen, Zhuo Georgia
    Khuri, Fadlo R.
    Shin, Dong M.
    Amin, A. R. M. Ruhul
    CANCER LETTERS, 2015, 363 (02) : 166 - 175
  • [29] Metformin induces apoptosis of human hepatocellular carcinoma HepG2 cells by activating an AMPK/p53/miR-23a/FOXA1 pathway
    Sun, Yunpeng
    Tao, Chonglin
    Huang, Xiaming
    He, Han
    Shi, Hongqi
    Zhang, Qiyu
    Wu, Huanhuan
    ONCOTARGETS AND THERAPY, 2016, 9 : 2845 - 2853
  • [30] Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901
    Xing, Chungen
    Zhu, Baosong
    Liu, Huihui
    Yao, Huihua
    Zhang, Lifeng
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2008, 40 (03) : 194 - 201
12345