Architecture of the RNA polymerase II preinitiation complex and mechanism of ATP-dependent promoter opening

被引：0
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作者：
Sebastian Grünberg
Linda Warfield
Steven Hahn
机构：
[1] Fred Hutchinson Cancer Research Center,
来源：
Nature Structural & Molecular Biology | 2012年 / 19卷
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摘要：
The general transcription factors TFIIE and TFIIH subunit Ssl2/XPB function in the transition of the preinitiation complex (PIC) to the open polymerase II (Pol II) complex. Efforts to localize TFIIE and Ssl2 in the yeast PIC now reveal crucial roles for the three TFIIE winged-helix domains and for Ssl2 in promoting DNA strand separation.
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页码：788 / 796
页数：8
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