Effects of delta-sleep-inducing peptide on NMDA-induced convulsive activity in rats

被引：11

作者：

Shandra A.A. ^{[1
]}

Godlevskii L.S. ^{[1
]}

Brusentsov A.I. ^{[1
]}

Karlyuga V.A. ^{[1
]}

机构：

[1] Department of Normal Physiology, State Medical University, 270100 Odessa

来源：

Neuroscience and Behavioral Physiology | 1998年 / 28卷 / 6期

关键词：

Delta-sleep-inducing peptide; Epileptic activity; NMDA;

D O I：

10.1007/BF02462991

中图分类号：

学科分类号：

摘要：

Acute experiments on rats showed that the ED100 of NMDA for induction of clonic convulsions was 0.53 μg, while the ED100 of NMDA for inducing tonic extension of the forelimbs was 5.02 μg/animal. Determination of these parameters after administration of delta-sleep-inducing peptide (100 μg/kg, i.p.) revealed 2.3- and 4.46-fold increases. These results provide evidence for a neuroprotective role of delta-sleep-inducing peptide in relation to excitatory amino acid receptor agonists. ©1998 Plenum Publishing Corporation.

引用

页码：694 / 697

页数：3

共 7 条

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