Clozapine efficacy in tardive dyskinesia in schizophrenic patients

被引：0

作者：

D.P. Bassitt

Mário Rodrigues Louzã Neto

机构：

[1] Institute of Psychiatry,

[2] Medical School,undefined

[3] University of São Paulo,undefined

[4] Av. Dr. Ovidio Dires de Campos,undefined

[5] S/N,undefined

[6] São Paulo - SP,undefined

[7] CEP 05403-010,undefined

[8] Brasil,undefined

来源：

European Archives of Psychiatry and Clinical Neuroscience | 1998年 / 248卷

关键词：

Key words Tardive dyskinesia; Treatment; Clozapine; Schizophrenia;

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摘要：

Tardive dyskinesia (TD) is a long-term severe complication of antipsychotic treatment, with mean prevalence of 20–35%. The aim of this study was to evaluate effects of clozapine in severe TD. In an open trial seven patients with schizophrenia and severe TD were given clozapine for 6 months. Tardive dyskinesia severity was evaluated with AIMS and ESRS and schizophrenic psychopathology with PANSS. Clozapine mean dose at the end of the study was 392.86 mg/day. A mean reduction of 52% was observed in ESRS scores for TD. Two patients also had dystonic movements, and there was 50% reduction in one of them and complete remission in the other. There was also a 27% mean reduction in PANSS scores. Clozapine seems to be an alternative in the treatment of schizophrenic patients with severe TD.

引用

页码：209 / 211

页数：2