Molecular mechanisms of acetylcholine receptor-lipid interactions: From model membranes to human biology

被引：16

作者：

Baenziger J.E. ^{[1
]}

daCosta C.J.B. ^{[2
]}

机构：

[1] Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON

[2] Receptor Biology Laboratory, Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN

来源：

Biophysical Reviews | 2013年 / 5卷 / 1期

关键词：

Cys-loop receptors; Lipid rafts; Lipid-protein interactions; Nicotinic receptor trafficking; Pentameric ligand-gated ion channels; Phospholipase activity; Synaptic plasticity; Uncoupled state;

D O I：

10.1007/s12551-012-0078-7

中图分类号：

学科分类号：

摘要：

Lipids are potent modulators of the Torpedo nicotinic acetylcholine receptor. Lipids influence nicotinic receptor function by allosteric mechanisms, stabilizing varying proportions of pre-existing resting, open, desensitized, and uncoupled conformations. Recent structures reveal that lipids could alter function by modulating transmembrane α-helix/α-helix packing, which in turn could alter the conformation of the allosteric interface that links the agonist-binding and transmembrane pore domains-this interface is essential in the coupling of agonist binding to channel gating. We discuss potential mechanisms by which lipids stabilize different conformational states in the context of the hypothesis that lipid-nicotinic receptor interactions modulate receptor function at biological synapses. © 2012 International Union for Pure and Applied Biophysics (IUPAB) and Springer.

引用

页码：1 / 9

页数：8

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