Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma: Current State and Recent Advances

被引：2
作者：
Yakob M. [1 ]
Fuentes L. [1 ]
Wang M.B. [2 ]
Abemayor E. [2 ]
Wong D.T.W. [1 ]
机构：
[1] Center for Oral/Head & Neck Oncology Research, School of Dentistry, University of California, Los Angeles, 73-017 CHS, 10833 Le Conte Avenue, Los Angeles, 90095, CA
[2] Department of Head and Neck Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA
来源：
Current Oral Health Reports | 2014年 / 1卷 / 2期
基金：
美国国家卫生研究院;
关键词：
Exosomes; Metabolomics; Methylomics; Microbiomics; Oral cancer; Oral fluid diagnostics; Oral squamous cell carcinoma; Proteomics; Salivaomics; Salivary biomarker; Salivary diagnostics; Transcriptomics;
D O I：
10.1007/s40496-014-0014-y
中图分类号：
学科分类号：
摘要：
Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity. Detection of OSCC is currently based on a thorough clinical oral examination combined with a biopsy for histological analysis. Most cases of OSCC are not detected until the cancer has developed into advanced stages; thus, a reliable early-stage diagnostic marker is needed. This literature review presents an overview of the status of current advances in salivary diagnostics for OSCC. Though many protein and mRNA salivary biomarkers have been identified that can detect OSCC with high sensitivity and specificity, the most discernable findings occur with the use of multiple markers. Studies that incorporate proteomic, transcriptomic, and potentially additional “omics”, including methylomics, need to be initiated to bring technology to clinical applications and allow the best use of saliva in diagnosing OSCC. © 2014, Springer International Publishing AG.
引用
收藏
页码：133 / 141
页数：8
相关论文
共 97 条
[1]  
Siegel R., Naishadham D., Jemal A., Cancer statistics, 2013, CA Cancer J Clin, 63, 1, pp. 11-30, (2013)
[2]  
Markopoulos A.K., Current aspects on oral squamous cell carcinoma, Open Dent J, 6, pp. 126-130, (2012)
[3]  
Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M., Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008, Int J Cancer, 27, 12, pp. 2893-2917, (2010)
[4]  
Parkin D.M., Bray F., Ferlay J., Pisani P., Global cancer statistics, 2002, CA Cancer J Clin, 55, 2, pp. 74-108, (2005)
[5]  
a report of the Surgeon General, J Calif Dent Assoc, 28, 9, pp. 685-695, (2000)
[6]  
Choi S., Myers J.N., Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy, J Dent Res, 87, 1, pp. 14-32, (2008)
[7]  
Zini A., Czerninski R., Sgan-Cohen H.D., Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites, J Oral Pathol Med, 39, 4, pp. 299-305, (2010)
[8]  
Decker J., Goldstein J.C., Risk factors in head and neck cancer, N Engl J Med, 306, 19, pp. 1151-1155, (1982)
[9]  
Sugimura T., Kumimoto H., Tohnai I., Fukui T., Matsuo K., Tsurusako S., Et al., Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms, J Oral Pathol Med, 35, 1, pp. 11-18, (2006)
[10]  
Brennan J.A., Boyle J.O., Koch W.M., Goodman S.N., Hruban R.H., Eby Y.J., Et al., Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck, N Engl J Med, 332, 11, pp. 712-717, (1995)
12345678910