Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma

被引：57
作者：
Andersen Y.M.F. [1 ]
Egeberg A. [1 ]
Skov L. [1 ]
Thyssen J.P. [1 ]
机构：
[1] Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, Hellerup
来源：
Current Dermatology Reports | 2017年 / 6卷 / 1期
关键词：
Atopic dermatitis; Autoimmune disease; Cancer; Cardiovascular disease; Comorbidities; Neuropsychiatric disease;
D O I：
10.1007/s13671-017-0168-7
中图分类号：
学科分类号：
摘要：
Purpose of Review: In this review article, we summarize the current evidence about atopic dermatitis (AD)-associated comorbidities, beyond the traditional atopic and allergic conditions. Recent Findings: Patients with AD may have an increased risk of cardiovascular diseases, certain malignancies, autoimmune diseases, and neuropsychiatric diseases. The causes of these associations are likely multifactorial and may include genetic predispositions, systemic low-grade inflammation, environmental exposures, medication, and lifestyle and behavioral risk factors. There appears to be geographical variations in prevalence of comorbidities in patients with AD, indicating that differences in ethnicity and lifestyle factors may significantly influence the risk of certain comorbidities. Summary: The reported comorbidities in recent literature emphasize the burden of disease in patients with AD. Early appropriate AD therapy, in combination with reduction of risk factors, may help prevention of certain comorbidities. The reported observations may generate hypotheses for future investigations in underlying risk factors for AD-associated comorbidities. © 2017, Springer Science+Business Media New York.
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页码：35 / 41
页数：6
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