Accurate laboratory measurement of geo-engineering properties of intact rock including uniaxial compressive strength (UCS) and modulus of elasticity (E) involves high costs and a substantial amount of time. For this reason, it is of great necessity to develop some relationships and models for estimating these parameters in rock engineering. The present study was conducted to forecast UCS and E in the sedimentary rocks using artificial neural networks (ANNs) and multivariable regression analysis (MLR). For this purpose, a total of 196 rock samples from four rock types (i.e., sandstone, conglomerate, limestone, and marl) were cored and subjected to comprehensive laboratory tests. To develop the predictive models, physical properties of studied rocks such as P wave velocity (Vp), dry density (γd), porosity, and water absorption (Ab) were considered as model inputs, while UCS and E were the output parameters. We evaluated the performance of MLR and ANN models by calculating correlation coefficient (R), mean absolute error (MAE), and root-mean-square error (RMSE) indices. The comparison of the obtained results revealed that ANN outperforms MLR when predicting the UCS and E.