In ovarian cancer the prognostic influence of HER2/neu is not dependent on the CXCR4/SDF-1 signalling pathway

被引：0
作者：
D Pils
A Pinter
J Reibenwein
A Alfanz
P Horak
B C Schmid
L Hefler
R Horvat
A Reinthaller
R Zeillinger
M Krainer
机构：
[1] Medical University of Vienna,Department of Internal Medicine I, Division of Oncology
[2] Waehringer Guertel 18-20,Department of Obstetrics and Gynecology, Division of Gynecology
[3] Vienna A-1090,undefined
[4] Austria,undefined
[5] Medical University of Vienna,undefined
[6] Clinical Pathology,undefined
[7] Medical University of Vienna,undefined
来源：
British Journal of Cancer | 2007年 / 96卷
关键词：
ovarian cancer; immunohistochemistry; tissue microarray;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
HER2/neu overexpression is a driving force in the carcinogenesis of several human cancers. In breast cancer the prognostic influence of HER2/neu was shown to be at least partly based on increased metastatic potential mediated by the chemokine–chemokine receptor pair SDF-1(CXCL12)/CXCR4. We wanted to evaluate the influence of HER2/neu on ovarian cancer prognosis and to investigate whether compromised survival would correlate with CXCR4 expression and/or SDF-1 abundance. Therefore, we analysed HER2/neu, CXCR4, and SDF-1 in 148 ovarian tumour samples by means of immunohistochemistry on tissue microarrays. Overexpression of HER2/neu was found in 27.6% of ovarian cancer tissues and in 15% of ovarian borderline tumours. In ovarian cancer patients, overexpression of HER2/neu correlated closely with overall survival (univariate hazard ratio (HR) 2.59, P=0.005; multiple corrected HR 1.92, P=0.074). In contrast, CXCR4 expression and SDF-1 abundance had no impact on overall survival, and both parameters were not correlated with HER2/neu expression. As expected, cytoplasmic CXCR4 expression and SDF-1 abundance correlated closely (P<0.0001). Our results confirm a univariate influence of HER2/neu expression on overall survival, which was completely independent of the expression of CXCR4 and the abundance of SDF-1, implying significant differences between the HER2/neu downstream pathways in ovarian cancer compared with breast cancer.
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页码：485 / 491
页数：6
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