Immunotherapy with internally inactivated virus loaded dendritic cells boosts cellular immunity but does not affect feline immunodeficiency virus infection course

被引：0
作者：
Giulia Freer
Donatella Matteucci
Paola Mazzetti
Francesca Tarabella
Enrica Ricci
Leonia Bozzacco
Antonio Merico
Mauro Pistello
Luca Ceccherini-Nelli
Mauro Bendinelli
机构：
[1] University of Pisa,Retrovirus Center and Virology Section, Department of Experimental Pathology
来源：
Retrovirology | / 5卷
关键词：
Human Immunodeficiency Virus; Imiquimod; Feline Immunodeficiency Virus; Proviral Load; Simian Immunodeficiency Virus Infection;
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摘要：
Immunotherapy of feline immunodeficiency virus (FIV)-infected cats with monocyte-derived dendritic cells (MDCs) loaded with aldrithiol-2 (AT2)-inactivated homologous FIV was performed. Although FIV-specific lymphoproliferative responses were markedly increased, viral loads and CD4+ T cell depletion were unaffected, thus indicating that boosting antiviral cell-mediated immunity may not suffice to modify infection course appreciably.
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