Biodistribution and Radiation Dosimetry of the Serotonin 5-HT6 Ligand [11C]GSK215083 Determined from Human Whole-Body PET

被引:0
作者
Robert A. Comley
Cristian Salinas
Romina Mizrahi
Irina Vitcu
Alvina Ng
William Hallett
Nicholas Keat
Alan A. Wilson
Eugenii A. Rabiner
Marc Laruelle
Sylvain Houle
机构
[1] GlaxoSmithKline Clinical Imaging Centre,
[2] Centre for Addiction and Mental Health,undefined
来源
Molecular Imaging and Biology | 2012年 / 14卷
关键词
Biodistribution; Dosimetry; Positron emission tomography; [; C]GSK215083; 5-HT; antagonist;
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页码:517 / 521
页数:4
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共 92 条
[1]  
Ruat M(1993)A novel rat serotonin (5-HT Biochem Biophys Res Commun 193 268-276
[2]  
Traiffort E(1993)) receptor: molecular cloning, localization and stimulation of cAMP accumulation Mol Pharmacol 43 320-327
[3]  
Arrang JM(2006)Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs J Neuroimmunol 178 24-29
[4]  
Tardivel-Lacombe J(2000)Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques Brain Behav Immun 14 219-224
[5]  
Diaz J(1995)mRNA expression of serotonin receptors in cells of the immune tissues of the rat J Pharmacol Exp Ther 274 173-180
[6]  
Leurs R(1998)Determination of the role of the 5-ht6 receptor in the rat brain: a study using antisense oligonucleotides Br J Pharmacol 125 1562-1566
[7]  
Monsma FJ(1999)Involvement of 5-HT Br J Pharmacol 126 1537-1542
[8]  
Shen Y(2004) receptors in nigro-striatal function in rodents Synapse 51 158-164
[9]  
Ward RP(2001)Investigation of stretching behaviour induced by the selective 5-HT Neuropharmacology 41 210-219
[10]  
Hamblin MW(2001) receptor antagonist, Ro 04–6790, in rats Psychopharmacology (Berl) 158 114-119