Effect of clonidine on potential-dependent sodium currents in sensory neurons

被引：0
作者：
I. E. Katina
B. V. Krylov
R. S. Khrustaleva
B. F. Shchegolev
V. A. Tsyrlin
机构：
[1] Russian Academy of Sciences,I. P. Pavlov Institute of Physiology
[2] Ministry of Health of the Russian Federation,V. A. Almazov Cardiology Research Institute
[3] I. P. Pavlov State Medical University,Institute of Cardiovascular Diseases
[4] A. A. Ukhtomskii Research Institute of Physiology,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2005年 / 139卷
关键词：
clonidine; adrenoreceptors; analgesia; sensory neurons; sodium channels;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In experiments on rat pups we studied the effect of clonidine on potential-dependent Na+ currents in dorsal root ganglia by the voltage clamp method. Clonidine decreased the amplitude of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium currents. The range of acting concentrations and the absence of modulatory effect of norepinephrine on the efficiency of clonidine-induced blockade of sodium currents suggest that this blockade results from a direct interaction of clonidine with sodium channels.
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页码：38 / 42
页数：4
相关论文
共 35 条
  • [1] Vislobokov A. I.(1999)undefined Eksp. Klin. Farmakol. 62 20-22
  • [2] Savos’kin A. L.(2003)undefined Sensorn. Sist. 17 7-23
  • [3] Katina I. E.(1999)undefined Ros. Fiziol. Zh. 85 110-118
  • [4] Shchegolev B. F.(1999)undefined Nat. Neurosci. 2 541-548
  • [5] Zadina D. E.(1993)undefined Anesthesiol. Intensivmed. Notfallmed. Schmerzther. 28 2-12
  • [6] Krylov B. V.(2001)undefined Anesthesiology 94 137-144
  • [7] Vilin Yu. Yu.(2003)undefined Anesthesiology 98 1237-1242
  • [8] Katina I. E.(2000)undefined Anesthesiology 93 382-394
  • [9] Podzorova S. A.(1997)undefined Am. J. Physiol. 273 R1580-1584
  • [10] Akopian A. N.(1996)undefined Science 273 801-803
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