Dopamine ligands and the stimulus effects of amphetamine: animal models versus human laboratory data

被引：0

作者：

L. H. Brauer

Andrew J. Goudie

Harriet de Wit

机构：

[1] Department of Psychiatry,

[2] Duke University,undefined

[3] 151-S VA Medical Center,undefined

[4] 508 Fulton Street,undefined

[5] Durham,undefined

[6] NC 27705,undefined

[7] USA,undefined

[8] Department of Psychology,undefined

[9] Liverpool University,undefined

[10] P.O. Box 147,undefined

[11] Liverpool L69 3BX,undefined

[12] UK,undefined

[13] Department of Psychiatry,undefined

[14] University of Chicago,undefined

[15] MC3077,undefined

[16] 5841 S. Maryland Avenue,undefined

[17] Chicago,undefined

[18] IL 60637,undefined

[19] USA,undefined

来源：

Psychopharmacology | 1997年 / 130卷

关键词：

Key words Amphetamine; Dopamine; Mechanisms; Animal models; Human subjects; Cocaine; Drug abuse;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Studies with laboratory animals have consistently demonstrated a role for dopamine in mediating the discriminative stimulus (i.e., interoceptive) effects of amphetamine. For example, D2 dopamine agonists mimic the discriminative stimulus effects of amphetamine and D1 and D2 dopamine antagonists generally block them. The discriminative stimulus effects of drugs in animals are believed to parallel their subjective effects in humans. Therefore, it is often assumed that dopamine plays a role in amphetamine-induced subjective effects in humans and it would be reasonable to expect that dopamine antagonists would block the subjective effects of amphetamine. Few studies have tested this hypothesis directly, and those that have have yielded inconsistent results. This paper will review data regarding the effects of dopamine agonists and antagonists on the discriminative stimulus effects of amphetamine in animals and its subjective effects in humans. Possible explanations for the discrepancies between animal and human data will be discussed, and classical assumptions underlying the use of animal models of drug effects will be examined.

引用

页码：2 / 13

页数：11