Paraquat and iron-dependent lipid peroxidationNADPH versus NADPH-generating systems

被引:0
作者
Y. Fernandez
F. Anglade
S. Mitjavila
机构
[1] INRA,Laboratoire des Xénobiotiques
来源
Biological Trace Element Research | 2000年 / 74卷
关键词
Iron; iron chelators; paraquat; redox cycling; lipid peroxidation; microsomes;
D O I
暂无
中图分类号
学科分类号
摘要
The aim of this work was to study the effect of paraquat (P2+) on NADPH iron-dependent lipid peroxidation (basal peroxidation) either in the presence of NADPH or in the presence of NADPH-generating systems.
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页码:191 / 201
页数:10
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  • [1] Trush M. A.(1982)Studies on the in vitro interaction of mitomycin c, nitrofurantoin and paraquat with pulmonary microsomes—stimulation of reactive oxygen-dependent lipid peroxidation Biochem. Pharmacol. 5 805-814
  • [2] Mimnaugh E. G.(1988)Adriamycin-induced lipid peroxidation in mitochondria and microsomes Biochem. Pharmacol. 37 3071-3077
  • [3] Gram T. E.(1988)Adriamycin-dependent peroxidation in rat liver and heart microsomes catalysed by iron chelates and ferritin -maximum peroxidation at low oxygen partial pressures Biochem. Pharmacol. 37 2893-2897
  • [4] Griffin-Green E.(1987)Human placental lipid peroxidation. II. NADPH and iron dependent stimulation of microsomal lipid peroxidation by paraquat Gen. Pharmacol. 18 373-378
  • [5] Zalaska M. M.(1994)Effect of paraquat on the malondialdehyde level in rat liver microsomes (in vitro) Arch. Toxicol. 68 187-192
  • [6] Erecinska M.(1995)Paraquat potentiates iron-induced microsomal lipid peroxidation: modulation by the diet lipid composition Redox Rep. 1 213-218
  • [7] Vile G. F.(1997)Potentiation of iron-induced lipid peroxidation by a series of bipyridyls in relation to their ability to reduce iron Toxicol. Lett. 93 65-71
  • [8] Winterbourn C. C.(1989)Synergistic interactions between NADPH-cytochrom P450 reductase, paraquat, and iron in the generation of active oxygen radicals Biochem. Pharmacol. 38 1779-1786
  • [9] Kenel M. F.(1991)Ferritin, lipid peroxidation and redox-cycling xenobiotics Free Radical Res. Commun. 12 107-114
  • [10] Bestervelt L. L.(1985)Ferritin and superoxide dependent lipid peroxidation J. Biol. Chem. 260 3275-3280