Role of Different Peptides for Cancer Immunotherapy

Due to the enormous benefits derived from host immune response, immunotherapy has been regarded among the most effective methods for defending against cancers. Nevertheless, developing robust solutions with strong biosecurity as well as the potential to modulate immunogenicity in an effective manner, continues to be a challenge. Peptides’ structural similarities to protein molecules endow them with tremendous ability to solve such issues by either specifically inducing immune responses or enhancing therapeutic effect. Peptide-based substances have a lot of potential as immunotherapeutic agents for treating a variety of cancers. The development of cancer vaccines as well as delivery mechanisms based on peptides by imitating the biological functions of protein having extremely specialized immuno-regulatory roles has been the subject of significant research. Thus, this review gives a systemic comprehension of cancer immunotherapy, role of the immune system, and how peptides pose a huge potential in cancer immunotherapeutic. The role of peptides as vaccine antigens and adjuvants, checkpoint blockades, in targeted delivery and in combinatorial therapies has been addressed. Recent research on the same has been summarised, which demonstrates their enormous advantages, thus allowing their clinical application for cancer immunotherapy in near future.