Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk

被引：0
作者：
Aditi Hazra
Charles S. Fuchs
Andrew T. Chan
Edward L. Giovannucci
David J. Hunter
机构：
[1] Harvard School of Public Health,Program in Molecular and Genetic Epidemiology, Department of Epidemiology
[2] Brigham and Women’s Hospital and Harvard Medical School,Channing Laboratory, Department of Medicine
[3] Dana-Farber Cancer Institute,Department of Medical Oncology
[4] Harvard School of Public Health,Department of Nutrition
来源：
Cancer Causes & Control | 2008年 / 19卷
关键词：
Polymorphism; pathway; Colorectal cancer; Colorectal adenoma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We evaluated the association of a polymorphism in TCF7L2 (RS12255372) in the WNT signaling pathway, which previously has been strongly associated with risk of Type II Diabetes, with colorectal cancer (CRC) and adenoma in the prospective Nurses’ Health Study (NHS) and Health Professionals Follow-up Study (HPFS) cohorts. Hyperinsulinemia may be related to the risk of colon adenoma and cancer, therefore this variant associated with reduced insulin secretion would be predicted to be inversely associated with colorectal cancer. Overall, in the NHS and HPFS, there was suggestive evidence for an inverse association associated with homozygosity for the minor allele of RS12255372 (TCF7L2 TT) and CRC (conditional and covariate adjusted OR = 0.63, 95% CI: 0.37–1.08; P for heterogeneity 0.52 for the association in women and men). In summary, the marginal association of the TCF7L2 SNP with CRC might be due to chance, but warrants further laboratory and epidemiological investigation.
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页码：975 / 980
页数：5
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