Triarylimidazoles-synthesis of 3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives as potent α-glucosidase inhibitors

被引：0

作者：

Sadia Naureen

Shazia Noreen

Areesha Nazeer

Muhammad Ashraf

Umber Alam

Munawar Ali Munawar

Misbahul Ain Khan

机构：

[1] University of the Punjab,Institute of Chemistry

[2] The Islamia University of Bahawalpur,Department of Chemistry

[3] The Islamia University of Bahawalpur,Department of Biochemistry and Biotechnology

来源：

Medicinal Chemistry Research | 2015年 / 24卷

关键词：

Multicomponent reactions; Benzil; Fisher indole synthesis; NMR spectra;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of new trisubstituted imidazoles-3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives (2a–2u) were synthesized and evaluated for their α-glucosidase inhibition. The new compounds showed significant α-glucosidase inhibitory activity as compared to the standard inhibitor acrabose. Structures of synthesized compounds were determined using FT-IR, Mass spectrometry, 1H NMR, 13C NMR, and elemental analyses.

引用

页码：1586 / 1595

页数：9

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