Actinomycetes as host cells for production of recombinant proteins

被引：0
作者：
Nobutaka Nakashima
Yasuo Mitani
Tomohiro Tamura
机构：
[1] National Institute of Advanced Industrial Science and Technology (AIST),Proteolysis and Protein Turnover Research Group, Research Institute of Genome
[2] Karolinska Institute,based Biofactory
[3] Graduate School of Agriculture,Center for Genomics and Bioinformatics (CGB)
[4] Hokkaido University,Laboratory of Molecular Environmental Microbiology
来源：
Microbial Cell Factories | / 4卷
关键词：
Recombinant Protein; Streptomyces; Rhodococcus; Lactococcus Lactis; Thiostrepton;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Actinomycetes (Actinobacteria) are highly attractive as cell factories or bioreactors for applications in industrial, agricultural, environmental, and pharmaceutical fields. Genome sequencing of several species of actinomycetes has paved the way for biochemical and structural analysis of important proteins and the production of such proteins as recombinants on a commercial scale. In this regard, there is a need for improved expression vectors that will be applicable to actinomycetes. Recent advancements in gene expression systems, knowledge regarding the intracellular environment, and identification and characterization of plasmids has made it possible to develop practicable recombinant expression systems in actinomycetes as described in this review.
引用
收藏
相关论文
共 166 条
[1]  
Kashima Y(2004)High-level production of hyperthermophilic cellulase in the Biosci Biotechnol Biochem 68 235-237
[2]  
Udaka S(1993)expression and secretion system Antonie Van Leeuwenhoek 64 137-143
[3]  
Udaka S(1998)Protein secretion in J Biotechnol 63 167-177
[4]  
Yamagata HY(2005)Construction of an efficient Microb Cell Fact 4 2-140
[5]  
Lam KHE(1997)system for extracellular production of heterologous proteins Trends Biotechnol 15 135-504
[6]  
Chow KC(1996)Protein secretion in Curr Opin Biotechnol 7 500-256
[7]  
Wong WKR(2004): an efficient way to increase the overall heterologous protein production Mol Biotechnol 28 241-449
[8]  
Loir YL(2001)Controlled overproduction of proteins by lactic acid bacteria Curr Opin Biotechnol 12 446-14035
[9]  
Azevedo V(2003)Expression in bacteria other than Microb Cell Fact 2 5-148
[10]  
Oliveira SC(2004)Appropriate glycosylation of recombinant proteins for human use: implications of choice of expression system Proc Natl Acad Sci USA 101 14031-5568
12345678910