Calcium as a Trigger for Cerebellar Long-Term Synaptic Depression

被引：0
作者：
Elizabeth A. Finch
Keiko Tanaka
George J. Augustine
机构：
[1] Duke University Medical Center,Department of Medicine
[2] Korea Institute of Science and Technology,Center for Functional Connectomics
来源：
The Cerebellum | 2012年 / 11卷
关键词：
Synaptic plasticity; Purkinje cell; IP3; Ca; channel; Protein kinase C;
D O I：
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中图分类号：
学科分类号：
摘要：
Cerebellar long-term depression (LTD) is a form of long-term synaptic plasticity that is triggered by calcium (Ca2+) signals in the postsynaptic Purkinje cell. This Ca2+ comes both from IP3-mediated release from intracellular Ca2+ stores, as well as from Ca2+ influx through voltage-gated Ca2+ channels. The Ca2+ signal that triggers LTD occurs locally within dendritic spines and is due to supralinear summation of signals coming from these two Ca2+ sources. The properties of this postsynaptic Ca2+ signal can explain several features of LTD, such as its associativity, synapse specificity, and dependence on the timing of synaptic activity, and can account for the slow kinetics of LTD expression. Thus, from a Ca2+ signaling perspective, LTD is one of the best understood forms of synaptic plasticity.
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页码：706 / 717
页数：11
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[1]  
Ito M(1982)Long-lasting depression of parallel fiber–Purkinje cell transmission induced by conjunctive stimulation of parallel fibers and climbing fibers in the cerebellar cortex Neurosci Lett 33 253-258
[2]  
Kano M(1982)Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells J Physiol 324 113-134
[3]  
Ito M(1985)Long-term depression of parallel fibre synapses following stimulation of climbing fibres Brain Res 342 357-360
[4]  
Sakurai M(1987)Synaptic modification of parallel fibre-Purkinje cell transmission in in vitro guinea-pig cerebellar slices J Physiol 394 463-480
[5]  
Tongroach P(1992)Brief dendritic calcium signals initiate long-lasting synaptic depression in cerebellar Purkinje cells Proc Natl Acad Sci USA 89 7051-7055
[6]  
Ekerot CF(1995)Temporal specificity of long-term depression in parallel fiber–Purkinje synapses in rat cerebellar slice Learn Mem 2 185-198
[7]  
Kano M(2000)Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons EMBO J 19 2765-2774
[8]  
Sakurai M(2000)Quantification of spread of cerebellar long-term depression with chemical two-photon uncaging of glutamate Proc Natl Acad Sci USA 97 8635-8640
[9]  
Konnerth A(2000)Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis Neuron 25 635-647
[10]  
Dreessen J(2000)Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins Neuron 28 499-510
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