Inhibitory activity of Plantago major L. on angiotensin I-converting enzyme

被引：0
作者：
Nguyen Xuan Nhiem
Bui Huu Tai
Phan Van Kiem
Chau Van Minh
Nguyen Xuan Cuong
Nguyen Huu Tung
Vu Kim Thu
Trinh Nam Trung
Hoang Le Tuan Anh
Sung-Hoon Jo
Hae-Dong Jang
Young-In Kwon
Young Ho Kim
机构：
[1] Chungnam National University,College of Pharmacy
[2] Vietnam Academy of Science and Technology (VAST),Institute of Marine Biochemistry
[3] Hannam University,Department of Food and Nutrition
来源：
Archives of Pharmacal Research | 2011年 / 34卷
关键词：
Angiotensin I-converting enzyme; Antihypertensive effect;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.
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页码：419 / 423
页数：4
相关论文
共 75 条
[1]  
Ahmad M.(1994)Acteoside: A new antihypertensive drug Phytother. Res. 9 525-527
[2]  
Rizwani G. H.(2009)Plantain ( J. Agric. Food Chem. 57 9268-9273
[3]  
Aftab K.(2003) L.) species as novel sources of flavonoid antioxidants Planta Med. 69 600-604
[4]  
Ahmad V. U.(1987)Immunomodulatory activities of flavonoids, monoterpenoids, triterpenoids, iridoid glycosides and phenolic compounds of Lab. Invest. 56 345-348
[5]  
Gilani A. H.(2010) species Phytother. Res. 24 1088-1094
[6]  
Ahmad S. P.(2003)The angiotensin I-converting enzyme Phytochemistry 62 219-228
[7]  
Beara I. N.(1998)Bioguided isolation of angiotensin-converting enzyme inhibitors from the seeds of Phytochemistry 47 1161-1162
[8]  
Lesjak M. M.(2004) L Helv. Chim. Acta 87 598-604
[9]  
Jovin E. D.(2001)Antioxidant flavonoids from leaves of Chem. Pharm. Bull. 49 1036-1038
[10]  
Balog K. J.(1975) L J. Hypertens. 10 13-26
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