End of Inevitability: Programming and Reprogramming

被引：0
作者：
Kursad Turksen
机构：
[1] Ottawa Hospital Research Institute,Regenerative Medicine Program, Sprott Centre for Stem Cell Research
来源：
Stem Cell Reviews and Reports | 2013年 / 9卷
关键词：
Programming; Reprogramming; Induced pluripotent stem cells; Epigenetic; Differentiation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Stem cell commitment and differentiation leading to functional cell types and organs has generally been considered unidirectional and deterministic. Starting first with a landmark study 50 years ago, and now with more recent observations, this paradigm has been challenged, necessitating a rethink of what constitutes both programming and reprogramming processes, and how we can use this new understanding for new approaches to drug discovery and regenerative medicine.
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页码：385 / 387
页数：2
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共 129 条
[1]  
Gurdon JB(1962)Developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles Journal of Embryology & Experimental Morphology 10 622-640
[2]  
Takahashi K(2006)Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 663-676
[3]  
Yamanaka S(2013)Induced pluripotent stem cells in medicine and biology Development 140 2457-2461
[4]  
Takahashi K(2012)Implications of Parkinson’s disease pathophysiology for the development of cell replacement strategies and drug discovery in neurodegenerative diseases CNS & Neurological Disorders Drug Targets 11 907-920
[5]  
Yamanaka S(2013)Return of results in translational iPS cell research: considerations for donor informed consent Stem Cell Research and Therapy 4 6-872
[6]  
Pan-Montojo F(2007)Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 861-726
[7]  
Funk RH(2013)Efficient generation of integration-free iPS cells from human adult peripheral blood using BCL-XL together with Yamanaka factors PLoS One 8 e64496-653
[8]  
Lomax GP(2011)E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming EMBO Reports 12 720-2601
[9]  
Shepard KA(2009)Direct reprogramming of human neural stem cells by OCT4 Nature 461 649-21
[10]  
Takahashi K(2012)Analysis of endogenous Oct4 activation during induced pluripotent stem cell reprogramming using an inducible Oct4 lineage label Stem Cells 30 2596-1284
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