Targeted protein destabilization reveals an estrogen-mediated ER stress response

被引：0
|
作者：
Kanak Raina
Devin J Noblin
Yevgeniy V Serebrenik
Alison Adams
Connie Zhao
Craig M Crews
机构：
[1] Yale University,Department of Chemistry
[2] Cellular and Developmental Biology,Department of Molecular
[3] Yale University,Department of Pharmacology
[4] Molecular Biophysics and Biochemistry,undefined
[5] Yale University,undefined
[6] Yale University,undefined
来源：
Nature Chemical Biology | 2014年 / 10卷
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摘要：
The use of an endoplasmic reticulum–localized HaloTag system results in protein destabilization and activation of a transient unfolding protein response (UPR) without causing cell death, allowing the examination of later stage UPR events.[graphic not available: see fulltext]
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页码：957 / 962
页数：5
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