Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence

被引：0
作者：
Evelyn Yu-Xin Tay
Yee-Leng Teoh
Matthew Sze-Wei Yeo
机构：
[1] Changi General Hospital,Department of Dermatology
[2] Tan Tock Seng Hospital,Department of Plastic Surgery
来源：
Dermatology and Therapy | 2019年 / 9卷
关键词：
Basal cell carcinoma; Hedgehog pathway inhibitors; Skin malignancy; Sonidegib; Vismodegib;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Basal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant minority of advanced BCC cases, including locally advanced BCC and metastatic BCC. The introduction of a novel class of drugs, the Hedgehog pathway inhibitors, into clinical practice has ushered in a new treatment algorithm for the treatment of difficult BCC cases. In this review we present the latest available evidence and discuss areas for further research in this rapidly evolving field.
引用
收藏
页码：33 / 49
页数：16
相关论文
共 222 条
[1]  
Rogers H(2015)Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the US population, 2012 JAMA Dermatol 151 1081-1086
[2]  
Weinstock M(1990)Systemic cytotoxic therapy of basal cell carcinoma: a review of the literature Eur J Cancer 26 73-77
[3]  
Feldman S(2007)Scratching the surface of skin development Nature 445 834-842
[4]  
Coldiron B(2009)Epidermal homeostasis: a balancing act of stem cells in the skin Nat Rev Mol Cell Biol 10 207-217
[5]  
Pfeiffer P(2008)Hedgehog: functions and mechanisms Genes Dev 22 2454-2472
[6]  
Hansen O(2008)Hedgehog signalling is essential for normal wound healing Wound Repair Regen 16 768-773
[7]  
Rose C(2008)Generation of human induced pluripotent stem cells form dermal fibroblasts Proc Natl Acad Sci USA 105 2883-2888
[8]  
Fuchs E(2006)Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis Hum Reprod 21 1698-1704
[9]  
Blanpain C(2004)Next stop, the twilight zone: Hedgehog network regulation of mammary gland development J Mammary Gland Biol Neoplasia 9 165-181
[10]  
Fuchs E(2007)Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways Proc Natl Acad Sci USA 104 5895-5900
12345678910