Effect of Leptin and Apelin Preconditioning on Hepatic Ischemia Reperfusion Injury in Rats

被引:0
作者
Tamer Sagiroglu
Mustafa Burak Aksoy
Gonul Sagiroglu
Hilmi Tozkir
Serhat Oguz
Tulin Yalta
Mehmet A. Yagci
Atakan Sezer
机构
[1] Trakya University,Faculty of Medicine Department of General Surgery
[2] Trakya University,Faculty of Medicine Department of Emergency Service
[3] Trakya University,Faculty of Medicine Department of Anesthesiology and Reanimation
[4] Trakya University,Faculty of Medicine Department of Medical Genetics
[5] Trakya University,Faculty of Medicine Department of Pathology
[6] Hakkari State Hospital,undefined
来源
Indian Journal of Surgery | 2014年 / 76卷
关键词
Ischemia reperfusion injury; Liver; Leptin; Apelin;
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学科分类号
摘要
Leptin and apelin are important adipocytokines involved in a variety of endocrine and paracrine functions. The aim of this study was to evaluate the effect of exogenous leptin and apelin preconditioning on hepatic ischemia reperfusion (I/R) injury in rats. Forty mice were assigned to four groups (n = 10): sham-operated control (sham), I/R injury, I/R + leptin (I/R + L), and I/R + apelin (I/R + A). Leptin 100 μg/kg/day and apelin 2 μg/kg/day were delivered intraperitoneally starting 3 days prior to surgical procedure in I/R + L and I/R + A groups, respectively. All I/R groups underwent 45 min of warm ischemia, followed by 30 min of reperfusion. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), liver malondialdehyde (MDA) and glutathione (GSH), and liver histopathology were compared between groups. MDA was elevated in I/R, but stayed similar in I/R + L and I/R + A compared to sham. I/R + A had significantly lower MDA compared to I/R. GSH levels did not differ significantly between the groups. ALT and AST were elevated in all I/R groups, but significant reduction was observed in I/R + L and I/R + A compared to I/R. Liver histopathology was mostly mild in I/R + L and I/R + A, in contrast to severe injury observed in the I/R group. Leptin and apelin preconditioning significantly reduced hepatic I/R injury in rats.
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页码:111 / 116
页数:5
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