Subcutaneous versus transvenous implantable cardioverter-defibrillator among drug-induced type-1 ECG pattern Brugada syndrome: a propensity score matching analysis from IBRYD study (Nov, 10.1007/s00380-022-02204-x, 2022)

被引：0

作者：

Russo, Vincenzo ^{[1
]}

Caturano, Alfredo ^{[2
]}

Guerra, Federico ^{[3
]}

Migliore, Federico ^{[4
]}

Mascia, Giuseppe ^{[5
]}

Rossi, Andrea ^{[6
]}

Nesti, Martina ^{[7
]}

Santobuono, Vincenzo Ezio ^{[8
]}

Attena, Emilio ^{[9
]}

Tola, Gianfranco ^{[10
]}

Sciarra, Luigi ^{[11
]}

Conte, Giulio ^{[12
]}

Perini, Alessandro Paoletti ^{[13
]}

Francia, Pietro ^{[14
]}

Dendramis, Gregory ^{[15
]}

Palama, Zefferino ^{[16
]}

Albani, Stefano ^{[17
]}

Ghidini, Andrea Ottonelli ^{[18
]}

Calo, Leonardo ^{[11
]}

D'Onofrio, Antonio ^{[19
]}

Baldi, Enrico ^{[20
]}

机构：

[1] Univ Campania Luigi Vanvitelli, Monaldi Hosp, Dept Med Translat Sci, Div Cardiol, Naples, Italy

[2] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Luigi Miraglia 2,T80138, Naples, Italy

[3] Azienda Osped Univ Osped Riuniti, Ancona, Italy

[4] Univ Padua, Padua, Italy

[5] IRCCS San Martino Polyclin Hosp, Genoa, Italy

[6] Gabriele Monasterio Fdn, Pisa, Italy

[7] Osped San Donato, Cardiovasc & Neurol Dept, Via Nenni 20-22, I-52100 Arezzo, Italy

[8] Univ Bari Aldo Moro, Dept Interdisciplinary Med & Policlin Bari, Cardiol Unit, Bari, Italy

[9] Roccadaspide Hosp, Cardiol Unit, ASL Salerno, Roccadaspide, Italy

[10] Azienda Osped Brotzu, Cagliari, Italy

[11] Policlin Casilino, Cardiol Unit, Rome, Italy

[12] Cardioctr Ticino Fdn, Lugano, Switzerland

[13] Azienda Sanit Firenze, Florence, Italy

[14] Azienda Osped Univ St Andrea, Rome, Italy

[15] Osped Civ Cristina Benfratelli, Cardiol Unit, Clin & Intervent Arrhythmol, ARNAS, Palermo, Italy

[16] Casa Cura Villa Verde, Taranto, Italy

[17] Umberto Parini Reg Hosp, Aosta, Italy

[18] Versilia Hosp, Cardiol Unit, Lido Di Camaiore LU, Italy

[19] Monaldi Hosp, Dept Unit Electrophysiol Evaluat & Treatment Arrhy, Naples, Italy

[20] IRCCS Policlin San Matteo, Pavia, Italy

来源：

HEART AND VESSELS | 2023年 / 38卷 / 05期

关键词：

Brugada syndrome; Drug-induced type 1 Brugada syndrome; ICD-related complication; ICD-related infection; Implantable cardioverter-defibrillator; Inappropriate shock; Subcutaneous cardioverter-defibrillator; Sudden cardiac death; Transvenous cardioverter-defibrillator;

D O I：

10.1007/s00380-022-02228-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

No real-world data are available about the complications rate in drug-induced type 1 Brugada Syndrome (BrS) patients with an implantable cardioverter-defibrillator (ICD). Aim of our study is to compare the device-related complications, infections, and inappropriate therapies among drug-induced type 1 BrS patients with transvenous- ICD (TV-ICD) versus subcutaneous-ICD (S-ICD). Data for this study were sourced from the IBRYD (Italian BRugada sYnDrome) registry which includes 619 drug-induced type-1 BrS patients followed at 20 Italian tertiary referral hospitals. For the present analysis, we selected 258 consecutive BrS patients implanted with ICD. 198 patients (76.7%) received a TV-ICD, while 60 a S-ICD (23.4%). And were followed-up for a median time of 84.3 [46.5–147] months. ICD inappropriate therapies were experienced by 16 patients (6.2%). 14 patients (7.1%) in the TVICD group and 2 patients (3.3%) in S-ICD group (log-rank P = 0.64). ICD-related complications occurred in 31 patients (12%); 29 (14.6%) in TV-ICD group and 2 (3.3%) in S-ICD group (log-rank P = 0.41). ICD-related infections occurred in 10 patients (3.88%); 9 (4.5%) in TV-ICD group and 1 (1.8%) in S-ICD group (log-rank P = 0.80). After balancing for potential confounders using the propensity score matching technique, no differences were found in terms of clinical outcomes between the two groups. In a real-world setting of drug-induced type-1 BrS patients with ICD, no significant differences in inappropriate ICD therapies, device-related complications, and infections were shown among S-ICD vs TV-ICD. However, a reduction in lead-related complications was observed in the S-ICD group. In conclusion, our evidence suggests that S-ICD is at least non-inferior to TV-ICD in this population and may also reduce the risk of lead-related complications which can expose the patients to the necessity of lead extractions. © 2022, The Author(s).

引用

页码：689 / 690

页数：2