Parathyroid and calcium status in patients with thalassemia

被引：18

作者：

Goyal M. ^{[1
]}

Abrol P. ^{[1
]}

Lal H. ^{[2
,3
]}

机构：

[1] Department of Pediatrics, Post Graduate Institute of Medical Sciences, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana

[2] Department of Biochemistry, Post Graduate Institute of Medical Sciences, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana

[3] Department of Biochemistry, Maharaja Agrasen Medical College, Agroha (Hissar), Haryana

来源：

Indian Journal of Clinical Biochemistry | 2010年 / 25卷 / 4期

关键词：

Calcium; Parathyroid hormone; Thalassemia;

D O I：

10.1007/s12291-010-0071-5

中图分类号：

学科分类号：

摘要：

Thirty patients with thalassemia major receiving repeated blood transfusion were studied to see their serum parathyroid hormone (PTH) and calcium status. Serum PTH, serum and 24 h urinary calcium, and serum alkaline phosphatase, phosphorus, and albumin-corrected calcium levels were determined. Half of these patients, in addition to transfusion, were also supplemented with vitamin D (60,000 IU for 10d) and calcium (1500 mg/day for 3 months). Serum PTH, and serum and 24 h urinary calcium concentrations of the patients receiving transfusions were found to be significantly reduced while their serum alkaline phosphatase, phosphorus, and albumin-corrected calcium levels were not significantly altered when compared to the respective mean values for the control group. Vitamin D and calcium supplementation significantly increased their serum PTH and calcium levels. Supplementations also increased urinary excretion of calcium. The results thus suggest that patients with thalassemia have hypoparathyroidism and reduced serum calcium concentrations that in turn were improved with vitamin D and calcium supplementation. © Association of Clinical Biochemists of India 2010.

引用

页码：385 / 387

页数：2

共 15 条

[1]

Huisman T.H.J., The structure and function of normal and abnormal haemoglobins, Bailliere's Clinical Haematology, 6, 1, pp. 1-30, (1993)

[2]

Thein S.L., β-Thalassemia, Clin Haematol, 6, pp. 151-175, (1993)

[3]

Cazzola M., De Stefano P., Ponchio L., Relationship between transfusion regimen and suppression of erythropoiesis in beta thalassemia major, Br J Haematol, 89, pp. 1-10, (1995)

[4]

Rombos Y., Tzanetea R., Konstantopoulos K., Simitzis S., Zervas C., Kyriaki P., Kavouklis M., Aessopos A., Sakellaropoulos N., Karagiorga M., Kalotychou V., Loukopoulos D., Chelation therapy in patients with thalassemia using the orally active iron chelator deferiprone (L1), Haematologica, 85, 2, pp. 115-117, (2000)

[5]

De Sanctis V., Vullo C., Bagni B., Chiccoli L., Hypoparathyroidism in beta-thalassemia major: Clinical and laboratory observations in 24 patients, Acta Haematologica, 88, 2-3, pp. 105-108, (1992)

[6]

Connerty H.V., Briggs A.R., Determination of serum calcium by means of orthocresolphthalein complexone, Am J Clin Pathol, 45, pp. 200-206, (1966)

[7]

Atkinson A., Gatenby A.D., Lowe A.G., The determination of inorganic orthophosphate in biological systems, Biochim Biophys Acta, 320, pp. 195-204, (1973)

[8]

Moss D.W., Whitby L.G., A simplified method for investigating alkaline phosphatase isoenzymes in serum, Clin Chim Acta, 40, pp. 35-41, (1972)

[9]

Doumas B.T., Peters Jr. T., Serum and urine albumin: A progress report on their measurement and clinical significance, Clinica Chimica Acta, 258, 1, pp. 3-20, (1997)

[10]

Payne R.B., Little A.J., Evans R.Y., Albumin-adjusted calcium concentration in serum increases during normal pregnancy, Clin Chem, 36, pp. 142-144, (1990)

← 1 2 →