Reducing TDP-43 aggregation does not prevent its cytotoxicity

被引：0
|
作者：
Rui Liu
Guang Yang
Takashi Nonaka
Tetsuaki Arai
William Jia
Max S Cynader
机构：
[1] University of British Columbia,Brain Research Center
[2] Tokyo Metropolitan Institute of Medical Science,Department of Neuropathology and Cell Biology
[3] University of Tsukuba,Department of Psychiatry, Graduate School of Comprehensive Human Sciences
来源：
Acta Neuropathologica Communications | / 1卷
关键词：
TDP-43; Aggregation; Peptides; Cell death;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Reducing TDP-43 aggregation does not prevent its cytotoxicity
    Liu, Rui
    Yang, Guang
    Nonaka, Takashi
    Arai, Tetsuaki
    Jia, William
    Cynader, Max S.
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2013, 1
  • [2] TDP-43 derived α-helical peptides: A novel strategy to prevent TDP-43 aggregation in neurodegenerative disorders
    Salaikumaran, Muthu Raj
    Gopal, Pallavi P.
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 169A - 169A
  • [3] DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
    Deshimaru, Manami
    Kinoshita-Kawada, Mariko
    Kubota, Kaori
    Watanabe, Takuya
    Tanaka, Yasuyoshi
    Hirano, Saito
    Ishidate, Fumiyoshi
    Hiramoto, Masaki
    Ishikawa, Mitsuru
    Uehara, Yoshinari
    Okano, Hideyuki
    Hirose, Shinichi
    Fujioka, Shinsuke
    Iwasaki, Katsunori
    Yuasa-Kawada, Junichi
    Mishima, Takayasu
    Tsuboi, Yoshio
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (08)
  • [4] Rational Design of TDP-43 Derived α-Helical Peptide Inhibitors: An In Silico Strategy to Prevent TDP-43 Aggregation in Neurodegenerative Disorders
    Salaikumaran, Muthu Raj
    Gopal, Pallavi P.
    ACS CHEMICAL NEUROSCIENCE, 2024, 15 (06): : 1096 - 1109
  • [5] Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
    Ormeno, Fernando
    Hormazabal, Juan
    Moreno, Jose
    Riquelme, Felipe
    Rios, Javiera
    Criollo, Alfredo
    Albornoz, Amelina
    Alfaro, Ivan E.
    Budini, Mauricio
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2020, 13
  • [6] Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation
    da Silva, Lara A. Gruijs
    Simonetti, Francesca
    Hutten, Saskia
    Riemenschneider, Henrick
    Sternburg, Erin L.
    Pietrek, Lisa M.
    Gebel, Jakob
    Doetsch, Volker
    Edbauer, Dieter
    Hummer, Gerhard
    Stelzl, Lukas S.
    Dormann, Dorothee
    EMBO JOURNAL, 2022, 41 (08):
  • [7] The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity
    Quan Li
    Moe Yokoshi
    Hitomi Okada
    Yukio Kawahara
    Nature Communications, 6
  • [8] The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity
    Li, Quan
    Yokoshi, Moe
    Okada, Hitomi
    Kawahara, Yukio
    NATURE COMMUNICATIONS, 2015, 6
  • [9] Inflammation Induces TDP-43 Mislocalization and Aggregation
    Correia, Ana Sofia
    Patel, Priyanka
    Dutta, Kallol
    Julien, Jean-Pierre
    PLOS ONE, 2015, 10 (10):
  • [10] TDP-43 aggregation reflects its loss of function at the proteome level
    Mihevc, S. Prpar
    Buratti, E.
    Baralle, M.
    Baralle, F. E.
    Rogelj, B.
    JOURNAL OF NEUROCHEMISTRY, 2016, 138 : 414 - 414
12345