Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases

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作者
Yuntao S. Mao
Helen L. Yin
机构
[1] University of Texas Southwestern Medical Center,Department of Physiology
关键词
PIP; PIP5K; Actin cytoskeleton; Arf6; Endocytosis; Phagocytosis;
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摘要
Phosphatidylinositol (4,5)-bisphosphate (PIP2) is an important lipid mediator that has multiple regulatory functions. There is now increasing evidence that the phosphatidylinositol 4-phosphate 5 kinases (PIP5Ks), which synthesize PIP2, are regulated spatially and temporally and that they have isoform-specific functions and regulations. This review will summarize the highlights of recent developments in understanding how the three major PIP5K isoforms regulate the actin cytoskeleton and other important cellular processes.
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