Liver fibrosis staging with contrast-enhanced ultrasonography: prospective multicenter study compared with METAVIR scoring

被引：0

作者：

F. Staub

C. Tournoux-Facon

J. Roumy

C. Chaigneau

M. Morichaut-Beauchant

P. Levillain

C. Prevost

C. Aubé

J. Lebigot

F. Oberti

J. B. Galtier

H. Laumonier

H. Trillaud

P. H. Bernard

J. F. Blanc

S. Sironneau

F. Machet

J. Drouillard

V. de Ledinghen

P. Couzigou

P. Foucher

L. Castéra

F. Tranquard

Y. Bacq

L. d’Altéroche

P. Ingrand

J. P. Tasu

机构：

[1] CHU de Poitiers,Department of Radiology

[2] CHU de Poitiers,Department of Hepatology

[3] CHU de Poitiers,Department of Pathology

[4] CHU de Poitiers,Centre d’investigation clinique INSERM CIC

[5] CHU d’Angers,P U802

[6] CHU de Tours,Radiology Department

[7] CHU de Bordeaux,Radiology Department

[8] CHU d’Angers,Radiology Departement

[9] CHU de Bordeaux,Hepatology Department

[10] CHU de Tours,Hepatology Department

[11] Fabrice Staub service de Radiologie,Hepatology Department

来源：

European Radiology | 2009年 / 19卷

关键词：

Liver; Fibrosis; Transit time; Contrast-enhanced sonography;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We prospectively assessed contrast-enhanced sonography for evaluating the degree of liver fibrosis as diagnosed via biopsy in 99 patients. The transit time of microbubbles between the portal and hepatic veins was calculated from the difference between the arrival time of the microbubbles in each vein. Liver biopsy was obtained for each patient within 6 months of the contrast-enhanced sonography. Histological fibrosis was categorized into two classes: (1) no or moderate fibrosis (F0, F1, and F2 according to the METAVIR staging) or (2) severe fibrosis (F3 and F4). At a cutoff of 13 s for the transit time, the diagnosis of severe fibrosis was made with a specificity of 78.57%, a sensitivity of 78.95%, a positive predictive value of 78.33%, a negative predictive value of 83.33%, and a performance accuracy of 78.79%. Therefore, contrast-enhanced ultrasound can help with differentiation between moderate and severe fibrosis.

引用

页码：1991 / 1997

页数：6

共 69 条

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