B-cell depletion in the treatment of lupus nephritis

被引：0
|
作者：
Jon W. Gregersen
David R. W. Jayne
机构：
[1] Aarhus University Hospital,Department of Nephrology
[2] The Vasculitis and Lupus Clinic,undefined
[3] Addenbrooke's Hospital,undefined
来源：
Nature Reviews Nephrology | 2012年 / 8卷
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摘要：
Lupus nephritis is the most common severe manifestation of the autoimmune disease systemic lupus erythematosus. Although conventional immunosuppressive therapy can increase survival, this approach is associated with considerable adverse effects. In this Review, Gregersen and Jayne discuss the available and future approaches to deplete B-cell populations and the current evidence for the therapeutic use of B cell depletion therapies in lupus nephritis, derived from case studies and clinical trials.
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页码：505 / 514
页数：9
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