The use of molecular genetic methods for prognosis of aerobic and anaerobic performance in athletes

被引：25

作者：

Ahmetov I.I. ^{[1
]}

Popov D.V. ^{[2
]}

Astratenkova I.V. ^{[1
]}

Druzhevskaya A.M. ^{[1
]}

Missina S.S. ^{[2
]}

Vinogradova O.L. ^{[2
]}

Rogozkin V.A. ^{[1
]}

机构：

[1] St. Petersburg Research Institute of Physical Culture

[2] Institute of Biomedical Problems, Russian Academy of Sciences

来源：

Human Physiology | 2008年 / 34卷 / 3期

关键词：

Aerobic Performance; UCP3 Gene; Anaerobic Performance; Molecular Genetic Method; Rowing Ergometer;

D O I：

10.1134/S0362119708030110

中图分类号：

学科分类号：

摘要：

The distribution of genotypes and alleles of ACE (I/D polymorphism), ACTN3 (R577X), NOS3 (5/4), UCP2 (Ala55 Val), and UCP3 (-55 C/T) genes, as well as the correlation between the genotype and physiological parameters, was studied in rowers (n = 230) and in a control group (n = 855). The genotypes were determined by analyzing restriction fragment length polymorphism. Physiological parameters were determined with a PM 3 rowing ergometer and a MetaMax 3B gas analyzer. The frequency of the ACE II genotype was significantly higher in elite rowers (n = 107) than in the control subjects. The frequency of the ACTN3 XX genotype, unfavorable for development of speed and strength qualities, was twofold lower in all rowers than in the control subjects. The frequencies of the ACE I, ACTN3 R, UCP2 Val, and UCP3 T alleles increased in the athletes along with an increase in skill, which suggested natural sports selection. In addition, ACE I, NOS3 5, UCP2 Val, and UCP3 T alleles correlated with a high aerobic performance. Thus, the ACE I, NOS3 5, UCP2 Val, and UCP3 T alleles may be regarded as genetic markers associated with enhanced aerobic performance and may be included in a diagnostic system for prognosis of human physical performance. © MAIK Nauka 2008.

引用

页码：338 / 342

页数：4

共 23 条

[1]

Rankinen T., Bray M.S., Hagberg J.M., Et al., The Human Gene Map for Performance and Health-Related Fitness Phenotypes: The 2005 Update, Med. Sci. Sports Exerc., 38, 11, (2006)

[2]

Myerson S., Hemingway H., Budget R., Et al., Human Angiotensin I-Converting Enzyme Gene and Endurance Performance, J. Appl. Physiol., 87, (1999)

[3]

Nazarov I.B., Woods D.R., Montgomery H.E., Et al., The Angiotensin-Converting Enzyme I/D Polymorphism in Russian Athletes, Eur. J. Hum. Genet., 9, (2001)

[4]

Hagberg J.M., Ferrel R.E., McCole S.D., Et al., VO<sub>2</sub> max Is Associated with ACE Genotype in Postmenopausal Women, J. Appl. Physiol., 85, 5, (1998)

[5]

Zhang B., Tanaka H., Shono N., Et al., The I Allele of the Angiotensin-Converting Enzyme Gene Is Associated with an Increased Percentage of Slow-Twitch Type I Fibers in Human Skeletal Muscles, Clin. Genet., 63, 2, (2003)

[6]

Montgomery H.E., Clarkson P., Dollery C.M., Et al., Association of Angiotensin-Converting Enzyme Gene I/D Polymorphism with Change in Left Ventricular Mass in Response to Physical Training, Circulation, 96, (1997)

[7]

Hagerman F.C., Applied Physiology of Rowing, Sports Med., 1, 4, (1984)

[8]

Gayagay G., Yu B., Hambly B., Et al., Elite Endurance Athletes and the ACE I Allele - The Role of Genes in Athletic Performance, Hum. Genet., 103, (1998)

[9]

Folland J., Leach B., Little T., Et al., Angiotensin-Converting Enzyme Genotype Affects the Response of Human Skeletal Muscle to Functional Overload, Exp. Physiol., 85, (2000)

[10]

Brull D., Vassiliou V., Jones A., Et al., Elite Swimmers and the D Allele of the ACE I/D Polymorphism, Hum. Genet., 108, (2001)

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